Seroatlas · Human Serome Atlas

PYCR3

Pyrroline-5-carboxylate reductase 3

Also known as: FLJ13852, P5CR3_HUMAN, PYCRL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53H96
Gene
PYCR3
Ensembl
ENSG00000104524
Chromosome
8
Canonical length
274 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytokinetic bridge,Mitotic spindle,Cytosol
Quaternary structure
Homodecamer

OverviewNCBI Gene

This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q53H96|PYCR3
     1  MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH FQALGCRTTH
    61  SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS VAAGVSLSTL EELLPPNTRV
   121  LRVLPNLPCV VQEGAIVMAR GRHVGSSETK LLQHLLEACG RCEEVPEAYV DIHTGLSGSG
   181  VAFVCAFSEA LAEGAVKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT
   241  TIYGLHALEQ GGLRAATMSA VEAATCRAKE LSRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYCR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • liver: 15 nTPM
  • cerebral cortex: 15 nTPM
  • hippocampal formation: 13 nTPM
  • amygdala: 12 nTPM
  • basal ganglia: 10 nTPM
  • kidney: 9.6 nTPM

Single-cell type

  • ependymal cells: 9.7 nCPM
  • brain excitatory neurons: 5.2 nCPM
  • other brain neurons: 4.9 nCPM
  • brain inhibitory neurons: 4.5 nCPM
  • bergmann glia: 3.1 nCPM
  • proximal tubule cells: 3.1 nCPM

Immune cell

  • naive B-cell: 4.8 nTPM
  • plasmacytoid DC: 3 nTPM
  • memory B-cell: 1.3 nTPM
  • NK-cell: 1.3 nTPM
  • MAIT T-cell: 1.2 nTPM
  • gdT-cell: 1.1 nTPM

Brain region

  • cerebral cortex: 8.8 nTPM
  • amygdala: 8.2 nTPM
  • cerebellum: 8.1 nTPM
  • thalamus: 7.9 nTPM
  • hippocampal formation: 7.7 nTPM
  • pons: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYCR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYCR3 as an antibody target. Whether an autoantibody or antibody against PYCR3 could matter depends on whether native PYCR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYCR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYCR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PYCR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...