Seroatlas · Human Serome Atlas

DECR1

2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

Also known as: DECR, DECR_HUMAN, SDR18C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16698
Gene
DECR1
Ensembl
ENSG00000104325
Chromosome
8
Canonical length
335 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Mitochondria,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

Enables 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in cytosol; mitochondrion; and nucleoplasm. Part of catalytic complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q16698|DECR1
     1  MKLPARVFFT LGSRLPCGLA PRRFFSYGTK ILYQNTEALQ SKFFSPLQKA MLPPNSFQGK
    61  VAFITGGGTG LGKGMTTLLS SLGAQCVIAS RKMDVLKATA EQISSQTGNK VHAIQCDVRD
   121  PDMVQNTVSE LIKVAGHPNI VINNAAGNFI SPTERLSPNA WKTITDIVLN GTAFVTLEIG
   181  KQLIKAQKGA AFLSITTIYA ETGSGFVVPS ASAKAGVEAM SKSLAAEWGK YGMRFNVIQP
   241  GPIKTKGAFS RLDPTGTFEK EMIGRIPCGR LGTVEELANL AAFLCSDYAS WINGAVIKFD
   301  GGEEVLISGE FNDLRKVTKE QWDTIEELIR KTKGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DECR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • liver: 70 nTPM
  • heart muscle: 33 nTPM
  • tongue: 33 nTPM
  • skeletal muscle: 27 nTPM
  • kidney: 25 nTPM
  • bone marrow: 24 nTPM

Single-cell type

  • late primary spermatocytes: 433 nCPM
  • parietal cells: 354 nCPM
  • neutrophils: 333 nCPM
  • hepatocytes: 318 nCPM
  • enterocytes: 304 nCPM
  • esophageal apical cells: 303 nCPM

Immune cell

  • neutrophil: 15 nTPM
  • intermediate monocyte: 10 nTPM
  • T-reg: 9.7 nTPM
  • non-classical monocyte: 9.3 nTPM
  • classical monocyte: 9 nTPM
  • myeloid DC: 8.8 nTPM

Brain region

  • choroid plexus: 56 nTPM
  • thalamus: 42 nTPM
  • basal ganglia: 40 nTPM
  • hypothalamus: 38 nTPM
  • midbrain: 38 nTPM
  • cerebral cortex: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DECR1.

Disease | AllUniProt

Conditions DECR1 is implicated in, by any mechanism.

  • 2,4-dienoyl-CoA reductase deficiency (DECRD) MIM:616034

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DECR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DECR1 as an antibody target. Whether an autoantibody or antibody against DECR1 could matter depends on whether native DECR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DECR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DECR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DECR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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