Seroatlas · Human Serome Atlas

SDR42E1

Short-chain dehydrogenase/reductase family 42E member 1

Also known as: D42E1_HUMAN, HSPC105

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUS8
Gene: SDR42E1
Ensembl: ENSG00000184860
Chromosome: 16
Canonical length: 393 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q8WUS8|SDR42E1
     1  MDPKRSQKES VLITGGSGYF GFRLGCALNQ NGVHVILFDI SSPAQTIPEG IKFIQGDIRH
    61  LSDVEKAFQD ADVTCVFHIA SYGMSGREQL NRNLIKEVNV RGTDNILQVC QRRRVPRLVY
   121  TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE QKVLEANATP LDRGDGVLRT
   181  CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR
   241  ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI
   301  LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF KAHGHGRSSG
   361  SRDSECFVWD GLLVFLLIIA VLMWLPSSVI LSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDR42E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

skin: 8.7 nTPM
duodenum: 5.3 nTPM
small intestine: 4.4 nTPM
breast: 4.1 nTPM
esophagus: 3.4 nTPM
pancreas: 3 nTPM

Single-cell type

podocytes: 17 nCPM
esophageal suprabasal cells: 16 nCPM
suprabasal keratinocytes: 15 nCPM
esophageal basal cells: 14 nCPM
breast lactating cells: 13 nCPM
pancreatic duct cells: 11 nCPM

Immune cell

memory B-cell: 2.3 nTPM
naive CD4 T-cell: 2.2 nTPM
NK-cell: 2 nTPM
naive CD8 T-cell: 1.6 nTPM
T-reg: 1.5 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

hypothalamus: 0.8 nTPM
basal ganglia: 0.6 nTPM
choroid plexus: 0.5 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.5 nTPM
midbrain: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -1.78
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

steroid biosynthetic process

Molecular functions

NAD or NADP as acceptor
oxidoreductase activity
acting on the CH-OH group of donors

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDR42E1 as an antibody target. Whether an autoantibody or antibody against SDR42E1 could matter depends on whether native SDR42E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDR42E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDR42E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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