Seroatlas · Human Serome Atlas

UEVLD

Ubiquitin-conjugating enzyme E2 variant 3

Also known as: Attp, UEV3, UEVLD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX04
Gene: UEVLD
Ensembl: ENSG00000151116
Chromosome: 11
Canonical length: 471 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q8IX04|UEVLD
     1  MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
    61  VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
   121  KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
   181  TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
   241  SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
   301  YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
   361  EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
   421  INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UEVLD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skin: 14 nTPM
rectum: 13 nTPM
colon: 13 nTPM
kidney: 11 nTPM
breast: 11 nTPM
cervix: 11 nTPM

Single-cell type

adrenal cortex cells: 64 nCPM
distal convoluted tubule cells: 59 nCPM
myonuclei: 58 nCPM
fibro-adipogenic progenitors: 56 nCPM
prostatic glandular cells: 54 nCPM
adipocytes: 53 nCPM

Immune cell

neutrophil: 6.2 nTPM
NK-cell: 5.1 nTPM
intermediate monocyte: 5 nTPM
classical monocyte: 4.8 nTPM
basophil: 4.2 nTPM
gdT-cell: 4 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 22 nTPM
basal ganglia: 20 nTPM
pons: 19 nTPM
thalamus: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UEVLD as an antibody target. Whether an autoantibody or antibody against UEVLD could matter depends on whether native UEVLD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UEVLD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UEVLD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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