ADH1C

Protein identityUniProt · HPA

UniProt accession

P00326

Gene

ADH1C

Ensembl

ENSG00000248144

Chromosome

4

Canonical length

375 aa

Protein class

Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Primary cilium,Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>P00326|ADH1C
     1  MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD EHVVSGNLVT
    61  PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRICKNPESN YCLKNDLGNP
   121  RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG
   181  YGSAVKVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE
   241  CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
   301  NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI LPFEKINEGF
   361  DLLRSGKSIR TVLTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADH1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

1,927 nTPM

Expression across tissuesHPA

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• retinoic acid metabolic process
• retinol metabolic process

Molecular functions

• alcohol dehydrogenase (NAD+) activity
• all-trans-retinol dehydrogenase (NAD+) activity
• zinc ion binding
• ethanol dehydrogenase (NAD+) activity

Cellular components

• ciliary basal body
• ciliary transition zone
• cilium
• cytosol
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Alcohol dehydrogenase, zinc-type, conserved site
• GroES-like superfamily
• Alcohol dehydrogenase-like, C-terminal
• Alcohol dehydrogenase-like, N-terminal
• Enoylreductase domain
• NAD(P)-binding domain superfamily
• Zinc-binding dehydrogenase
• Alcohol dehydrogenase GroES-like domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Metal-binding
• NAD
• Oxidoreductase
• Phosphoprotein
• Zinc