Seroatlas · Human Serome Atlas

DHRS4

Dehydrogenase/reductase SDR family member 4

Also known as: DHRS4_HUMAN, FLJ11008, humNRDR, SCAD-SRL, SDR-SRL, SDR25C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTZ2
Gene: DHRS4
Ensembl: ENSG00000157326
Chromosome: 14
Canonical length: 278 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including ketone metabolic process; positive regulation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q9BTZ2|DHRS4
     1  MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR RLAQDGAHVV
    61  VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV ATAVKLHGGI DILVSNAAVN
   121  PFFGSIMDVT EEVWDKTLDI NVKAPALMTK AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS
   181  PYNVSKTALL GLTKTLAIEL APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR
   241  RLGEPEDCAG IVSFLCSEDA SYITGETVVV GGGTPSRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

liver: 118 nTPM
kidney: 101 nTPM
skeletal muscle: 63 nTPM
heart muscle: 50 nTPM
esophagus: 47 nTPM
adrenal gland: 46 nTPM

Single-cell type

enterocytes: 36 nCPM
megakaryocytes: 25 nCPM
hepatocytes: 22 nCPM
proximal tubule cells: 15 nCPM
epididymal efferent duct absorptive cells: 15 nCPM
hepatic stellate cells: 13 nCPM

Immune cell

classical monocyte: 55 nTPM
myeloid DC: 48 nTPM
intermediate monocyte: 46 nTPM
plasmacytoid DC: 40 nTPM
total PBMC: 36 nTPM
non-classical monocyte: 26 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 11 nTPM
white matter: 11 nTPM
thalamus: 10 nTPM
basal ganglia: 10 nTPM
cerebellum: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -1.51
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS4 as an antibody target. Whether an autoantibody or antibody against DHRS4 could matter depends on whether native DHRS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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