GLYR1

Protein identityUniProt · HPA

UniProt accession

Q49A26

Gene

GLYR1

Ensembl

ENSG00000140632

Chromosome

16

Canonical length

553 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables several functions, including chromatin-protein adaptor activity; methylated histone binding activity; and nucleosome binding activity. Involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Located in cytosol and nucleoplasm. Part of nucleosome. Is active in chromatin. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q49A26|GLYR1
     1  MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL
    61  KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHNSSDDKNR RNSSEERSRP
   121  NSGDEKRKLS LSEGKVKKNM GEGKKRVSSG SSERGSKSPL KRAQEQSPRK RGRPPKDEKD
   181  LTIPESSTVK GMMAGPMAAF KWQPTASEPV KDADPHFHHF LLSQTEKPAV CYQAITKKLK
   241  ICEEETGSTS IQAADSTAVN GSITPTDKKI GFLGLGLMGS GIVSNLLKMG HTVTVWNRTA
   301  EKCDLFIQEG ARLGRTPAEV VSTCDITFAC VSDPKAAKDL VLGPSGVLQG IRPGKCYVDM
   361  STVDADTVTE LAQVIVSRGG RFLEAPVSGN QQLSNDGMLV ILAAGDRGLY EDCSSCFQAM
   421  GKTSFFLGEV GNAAKMMLIV NMVQGSFMAT IAEGLTLAQV TGQSQQTLLD ILNQGQLASI
   481  FLDQKCQNIL QGNFKPDFYL KYIQKDLRLA IALGDAVNHP TPMAAAANEV YKRAKALDQS
   541  DNDMSAVYRA YIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLYR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

57 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

2.34

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• transcription elongation-coupled chromatin remodeling
• transcription initiation-coupled chromatin remodeling

Molecular functions

• chromatin binding
• chromatin-protein adaptor activity
• DNA binding
• histone binding
• NAD binding
• NADP binding
• nucleosome binding

Cellular components

• chromatin
• cytosol
• nucleoplasm
• nucleosome

Protein domainsUniProt · Pfam · InterPro

• PWWP domain
• 6-phosphogluconate dehydrogenase, NADP-binding
• 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
• 6-phosphogluconate dehydrogenase, domain 2
• 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain
• NAD(P)-binding domain superfamily
• PWWP domain
• NAD binding domain of 6-phosphogluconate dehydrogenase
• NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
• Cytokine-like nuclear factor N-PAC, PWWP domain
• HIBADH-related NP60 subfamily

KeywordsUniProt

• Chromosome
• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of GLYR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GATA4
• KDM1B
• MAPK14
• NPM1