Seroatlas · Human Serome Atlas

HSD17B6

17-beta-hydroxysteroid dehydrogenase type 6

Also known as: H17B6_HUMAN, HSE, RODH, SDR9C6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14756
Gene: HSD17B6
Ensembl: ENSG00000025423
Chromosome: 12
Canonical length: 317 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>O14756|HSD17B6
     1  MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD ARGLRVLAAC
    61  LTEKGAEQLR GQTSDRLETV TLDVTKMESI AAATQWVKEH VGDRGLWGLV NNAGILTPIT
   121  LCEWLNTEDS MNMLKVNLIG VIQVTLSMLP LVRRARGRIV NVSSILGRVA FFVGGYCVSK
   181  YGVEAFSDIL RREIQHFGVK ISIVEPGYFR TGMTNMTQSL ERMKQSWKEA PKHIKETYGQ
   241  QYFDALYNIM KEGLLNCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAKFF FIPLSYLPTS
   301  LADYILTRSW PKPAQAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 1,686 nTPM

Expression across tissuesHPA

Tissue

liver: 1,686 nTPM
seminal vesicle: 65 nTPM
lung: 60 nTPM
prostate: 48 nTPM
spleen: 45 nTPM
urinary bladder: 35 nTPM

Single-cell type

hepatocytes: 2,398 nCPM
transitional alveolar cells: 255 nCPM
alveolar cells type 2: 186 nCPM
smooth muscle cells: 111 nCPM
alveolar cells type 1: 90 nCPM
prostatic glandular cells: 59 nCPM

Immune cell

MAIT T-cell: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM
gdT-cell: 1 nTPM
T-reg: 1 nTPM
memory CD4 T-cell: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

basal ganglia: 16 nTPM
midbrain: 13 nTPM
cerebral cortex: 12 nTPM
thalamus: 11 nTPM
cerebellum: 9.9 nTPM
amygdala: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.35
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

early endosome membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B6 as an antibody target. Whether an autoantibody or antibody against HSD17B6 could matter depends on whether native HSD17B6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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