Seroatlas · Human Serome Atlas

UXS1

UDP-glucuronic acid decarboxylase 1

Also known as: FLJ23591, SDR6E1, UGD, UXS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBZ7
Gene
UXS1
Ensembl
ENSG00000115652
Chromosome
2
Canonical length
420 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q8NBZ7|UXS1
     1  MVSKALLRLV SAVNRRRMKL LLGIALLAYV ASVWGNFVNM RSIQENGELK IESKIEEMVE
    61  PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV GSHLTDKLMM DGHEVTVVDN
   121  FFTGRKRNVE HWIGHENFEL INHDVVEPLY IEVDQIYHLA SPASPPNYMY NPIKTLKTNT
   181  IGTLNMLGLA KRVGARLLLA STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET
   241  MCYAYMKQEG VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ
   301  YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF LSEAQDDPQK
   361  RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN NQYIPKPKPA RIKKGRTRHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UXS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 56 nTPM
  • placenta: 51 nTPM
  • choroid plexus: 44 nTPM
  • lung: 43 nTPM
  • bone marrow: 38 nTPM
  • parathyroid gland: 35 nTPM

Single-cell type

  • platelets: 331 nCPM
  • undifferentiated spermatogonia: 142 nCPM
  • endometrial glandular cells: 139 nCPM
  • distal convoluted tubule cells: 132 nCPM
  • endometrial ciliated cells: 130 nCPM
  • endometrial luminal cells: 129 nCPM

Immune cell

  • T-reg: 131 nTPM
  • naive CD4 T-cell: 69 nTPM
  • memory CD4 T-cell: 65 nTPM
  • naive CD8 T-cell: 49 nTPM
  • total PBMC: 44 nTPM
  • memory CD8 T-cell: 41 nTPM

Brain region

  • thalamus: 79 nTPM
  • cerebellum: 77 nTPM
  • cerebral cortex: 73 nTPM
  • hippocampal formation: 67 nTPM
  • midbrain: 63 nTPM
  • white matter: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
2.09
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UXS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UXS1 as an antibody target. Whether an autoantibody or antibody against UXS1 could matter depends on whether native UXS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UXS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UXS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UXS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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