PGD

Protein identityUniProt · HPA

UniProt accession

P52209

Gene

PGD

Ensembl

ENSG00000142657

Chromosome

1

Canonical length

483 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Intermediate filaments,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>P52209|PGD
     1  MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE
    61  MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG
   121  ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG
   181  HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL
   241  KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA
   301  SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL
   361  MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM
   421  PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS
   481  YNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

483 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.29

gnomAD pLI

0.99

gnomAD missense Z

1.4

DepMap mean gene effect

-0.87

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• pentose biosynthetic process
• pentose-phosphate shunt
• pentose-phosphate shunt, oxidative branch
• D-gluconate metabolic process

Molecular functions

• carbohydrate binding
• carboxylic acid binding
• NADP binding
• phosphogluconate dehydrogenase (decarboxylating) activity

Cellular components

• cytosol
• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• 6-phosphogluconate dehydrogenase, NADP-binding
• 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
• 6-phosphogluconate dehydrogenase, domain 2
• NAD(P)-binding domain superfamily
• NAD binding domain of 6-phosphogluconate dehydrogenase
• 6-phosphogluconate dehydrogenase, decarboxylating
• 6-phosphogluconate dehydrogenase, C-terminal
• 6-phosphogluconate dehydrogenase
• 6-phosphogluconate-binding site
• 6-phosphogluconate dehydrogenase, C-terminal domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• NADP
• Oxidoreductase
• Pentose shunt
• Phosphoprotein
• Gluconate utilization