Seroatlas · Human Serome Atlas

WWOX

WW domain-containing oxidoreductase

Also known as: FOR, SDR41C1, WOX1, WWOX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZC7
Gene
WWOX
Ensembl
ENSG00000186153
Chromosome
16
Canonical length
414 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q9NZC7|WWOX
     1  MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP
    61  YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR
   121  DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWHKAKVEAM
   181  TLDLALLRSV QHFAEAFKAK NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV
   241  QLLQDVLCRS APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN
   301  ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK SMQQGAATTV
   361  YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WWOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 20 nTPM
  • spinal cord: 19 nTPM
  • midbrain: 18 nTPM
  • cerebellum: 18 nTPM
  • amygdala: 17 nTPM
  • basal ganglia: 17 nTPM

Single-cell type

  • ependymal cells: 3,105 nCPM
  • podocytes: 2,770 nCPM
  • choroid plexus epithelial cells: 2,148 nCPM
  • bergmann glia: 1,866 nCPM
  • astrocytes: 1,696 nCPM
  • renal collecting duct intercalated cells: 1,685 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • T-reg: 12 nTPM
  • MAIT T-cell: 12 nTPM
  • gdT-cell: 10 nTPM
  • NK-cell: 8.4 nTPM
  • naive CD4 T-cell: 8.1 nTPM

Brain region

  • white matter: 39 nTPM
  • medulla oblongata: 32 nTPM
  • cerebellum: 31 nTPM
  • midbrain: 31 nTPM
  • basal ganglia: 31 nTPM
  • hypothalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WWOX.

Disease | AllUniProt

Conditions WWOX is implicated in, by any mechanism.

  • Esophageal cancer (ESCR) MIM:133239
  • Spinocerebellar ataxia, autosomal recessive, 12 (SCAR12) MIM:614322
  • Developmental and epileptic encephalopathy 28 (DEE28) MIM:616211

Disease | GeneticClinVar

107 pathogenic / likely-pathogenic of 1,140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-4.44
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WWOX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WWOX as an antibody target. Whether an autoantibody or antibody against WWOX could matter depends on whether native WWOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WWOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WWOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WWOX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...