Seroatlas · Human Serome Atlas

AHCYL2

Adenosylhomocysteinase 3

Also known as: ADOHCYASE3, IRBIT2, KIAA0828, long-IRBIT, SAHH3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HN2
Gene: AHCYL2
Ensembl: ENSG00000158467
Chromosome: 7
Canonical length: 611 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>Q96HN2|AHCYL2
     1  MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
    61  PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
   121  KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
   181  KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
   241  VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
   301  GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
   361  DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
   421  TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
   481  SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
   541  TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
   601  NGPFKPNYYR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHCYL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 259 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 259 nTPM
rectum: 167 nTPM
colon: 147 nTPM
lung: 62 nTPM
duodenum: 54 nTPM
retina: 54 nTPM

Single-cell type

choroid plexus epithelial cells: 2,726 nCPM
pituicytes/fscs: 1,134 nCPM
retinal pigment epithelial cells: 848 nCPM
pituitary stem cells: 834 nCPM
renal collecting duct intercalated cells: 822 nCPM
astrocytes: 700 nCPM

Immune cell

T-reg: 1.8 nTPM
NK-cell: 1.3 nTPM
intermediate monocyte: 0.9 nTPM
eosinophil: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM
myeloid DC: 0.5 nTPM

Brain region

choroid plexus: 1,038 nTPM
hippocampal formation: 102 nTPM
thalamus: 85 nTPM
basal ganglia: 77 nTPM
cerebral cortex: 73 nTPM
hypothalamus: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 2.74
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AHCYL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHCYL2 as an antibody target. Whether an autoantibody or antibody against AHCYL2 could matter depends on whether native AHCYL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHCYL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHCYL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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