Seroatlas · Human Serome Atlas

PTGR3

Prostaglandin reductase 3

Also known as: MGC45594, PTGR-3, PTGR3_HUMAN, ZADH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4Q0
Gene
PTGR3
Ensembl
ENSG00000180011
Chromosome
18
Canonical length
377 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q8N4Q0|PTGR3
     1  MLRLVPTGAR AIVDMSYARH FLDFQGSAIP QAMQKLVVTR LSPNFREAVT LSRDCPVPLP
    61  GDGDLLVRNR FVGVNASDIN YSAGRYDPSV KPPFDIGFEG IGEVVALGLS ASARYTVGQA
   121  VAYMAPGSFA EYTVVPASIA TPVPSVKPEY LTLLVSGTTA YISLKELGGL SEGKKVLVTA
   181  AAGGTGQFAM QLSKKAKCHV IGTCSSDEKS AFLKSLGCDR PINYKTEPVG TVLKQEYPEG
   241  VDVVYESVGG AMFDLAVDAL ATKGRLIVIG FISGYQTPTG LSPVKAGTLP AKLLKKSASV
   301  QGFFLNHYLS KYQAAMSHLL EMCVSGDLVC EVDLGDLSPE GRFTGLESIF RAVNYMYMGK
   361  NTGKIVVELP HSVNSKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 42 nTPM
  • tongue: 38 nTPM
  • placenta: 34 nTPM
  • heart muscle: 32 nTPM
  • liver: 30 nTPM
  • retina: 28 nTPM

Single-cell type

  • peritubular myoid cells: 72 nCPM
  • podocytes: 68 nCPM
  • oligodendrocyte progenitor cells: 56 nCPM
  • corticotrophs: 51 nCPM
  • bergmann glia: 47 nCPM
  • leydig cells: 45 nCPM

Immune cell

  • eosinophil: 9 nTPM
  • non-classical monocyte: 3.8 nTPM
  • classical monocyte: 3.4 nTPM
  • gdT-cell: 3.2 nTPM
  • T-reg: 3.2 nTPM
  • intermediate monocyte: 2.9 nTPM

Brain region

  • cerebral cortex: 49 nTPM
  • cerebellum: 43 nTPM
  • pons: 42 nTPM
  • basal ganglia: 40 nTPM
  • hippocampal formation: 38 nTPM
  • spinal cord: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGR3 as an antibody target. Whether an autoantibody or antibody against PTGR3 could matter depends on whether native PTGR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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