STEAP4

Protein identityUniProt · HPA

UniProt accession

Q687X5

Gene

STEAP4

Ensembl

ENSG00000127954

Chromosome

7

Canonical length

459 aa

Protein class

Enzymes, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane

Quaternary structure

Homotrimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q687X5|STEAP4
     1  MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR NPQKTTLLPS
    61  GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI LVDISNNLKI NQYPESNAEY
   121  LAHLVPGAHV VKAFNTISAW ALQSGALDAS RQVFVCGNDS KAKQRVMDIV RNLGLTPMDQ
   181  GSLMAAKEIE KYPLQLFPMW RFPFYLSAVL CVFLFFYCVI RDVIYPYVYE KKDNTFRMAI
   241  SIPNRIFPIT ALTLLALVYL PGVIAAILQL YRGTKYRRFP DWLDHWMLCR KQLGLVALGF
   301  AFLHVLYTLV IPIRYYVRWR LGNLTVTQAI LKKENPFSTS SAWLSDSYVA LGILGFFLFV
   361  LLGITSLPSV SNAVNWREFR FVQSKLGYLT LILCTAHTLV YGGKRFLSPS NLRWYLPAAY
   421  VLGLIIPCTV LVIKFVLIMP CVDNTLTRIR QGWERNSKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STEAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

107 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0

gnomAD missense Z

0.84

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• copper ion import
• fat cell differentiation
• iron import into cell
• protein homotrimerization

Molecular functions

• cupric reductase (NADH) activity
• electron transfer activity
• FAD binding
• ferric-chelate reductase (NADPH) activity
• heme binding
• metal ion binding

Cellular components

• early endosome membrane
• endosome
• endosome membrane
• extracellular exosome
• Golgi membrane
• membrane
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Ferric reductase transmembrane component-like domain
• Pyrroline-5-carboxylate reductase, catalytic, N-terminal
• NAD(P)-binding domain superfamily
• STEAP family metalloreductases
• Ferric reductase like transmembrane component
• NADP oxidoreductase coenzyme F420-dependent

KeywordsUniProt

• Cell membrane
• Copper
• Electron transport
• Endosome
• FAD
• Flavoprotein
• Glycoprotein
• Golgi apparatus
• Heme
• Ion transport
• Iron
• Iron transport
• Membrane
• Metal-binding
• NADP
• Oxidoreductase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of STEAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTK2