ADH1A

Protein identityUniProt · HPA

UniProt accession

P07327

Gene

ADH1A

Ensembl

ENSG00000187758

Chromosome

4

Canonical length

375 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Primary cilium,Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>P07327|ADH1A
     1  MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD DHVVSGTMVT
    61  PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK CRICKNPESN YCLKNDVSNP
   121  QGTLQDGTSR FTCRRKPIHH FLGISTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG
   181  YGSAVNVAKV TPGSTCAVFG LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE
   241  CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
   301  NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV LPFEKINEGF
   361  DLLHSGKSIR TILMF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADH1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

2,560 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.6

gnomAD pLI

0

gnomAD missense Z

0.01

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• alcohol metabolic process
• retinoic acid metabolic process
• retinol metabolic process

Molecular functions

• alcohol dehydrogenase (NAD+) activity
• all-trans-retinol dehydrogenase (NAD+) activity
• zinc ion binding
• butanol dehydrogenase (NAD+) activity

Cellular components

• ciliary basal body
• ciliary transition zone
• cilium
• cytosol
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Alcohol dehydrogenase, zinc-type, conserved site
• GroES-like superfamily
• Alcohol dehydrogenase-like, C-terminal
• Alcohol dehydrogenase-like, N-terminal
• Enoylreductase domain
• NAD(P)-binding domain superfamily
• Zinc-binding dehydrogenase
• Alcohol dehydrogenase GroES-like domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Metal-binding
• NAD
• Oxidoreductase
• Phosphoprotein
• Zinc