Seroatlas · Human Serome Atlas

HSD17B14

L-fucose dehydrogenase

Also known as: DHB14_HUMAN, DHRS10, retSDR3, SDR47C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPX1
Gene: HSD17B14
Ensembl: ENSG00000087076
Chromosome: 19
Canonical length: 270 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9BPX1|HSD17B14
     1  MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE QELPGAVFIL
    61  CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE ETSAQGFRQL LELNLLGTYT
   121  LTKLALPYLR KSQGNVINIS SLVGAIGQAQ AVPYVATKGA VTAMTKALAL DESPYGVRVN
   181  CISPGNIWTP LWEELAALMP DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG
   241  IELLVTGGAE LGYGCKASRS TPVDAPDIPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 139 nTPM
liver: 83 nTPM
kidney: 58 nTPM
ovary: 58 nTPM
basal ganglia: 46 nTPM
parathyroid gland: 44 nTPM

Single-cell type

hofbauer cells: 295 nCPM
choroid plexus epithelial cells: 167 nCPM
epididymal efferent duct absorptive cells: 149 nCPM
proximal tubule cells: 86 nCPM
ovarian stromal cells: 71 nCPM
retinal pigment epithelial cells: 68 nCPM

Immune cell

NK-cell: 4.8 nTPM
memory B-cell: 3.7 nTPM
naive CD4 T-cell: 3.1 nTPM
naive B-cell: 2.5 nTPM
naive CD8 T-cell: 2.3 nTPM
MAIT T-cell: 1.5 nTPM

Brain region

choroid plexus: 112 nTPM
thalamus: 51 nTPM
cerebellum: 48 nTPM
midbrain: 46 nTPM
hypothalamus: 39 nTPM
amygdala: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding
D-threo-aldose 1-dehydrogenase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSD17B14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BRIP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B14 as an antibody target. Whether an autoantibody or antibody against HSD17B14 could matter depends on whether native HSD17B14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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