GLUD2

Protein identityUniProt · HPA

UniProt accession

P49448

Gene

GLUD2

Ensembl

ENSG00000182890

Chromosome

X

Canonical length

558 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

Quaternary structure

Homohexamer

OverviewNCBI Gene

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>P49448|GLUD2
     1  MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR RHYSELVADR
    61  EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF
   121  PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG
   181  GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY
   241  ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR
   301  DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG
   361  FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER
   421  NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLLSV QESLERKFGK
   481  HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV
   541  NAIEKVFKVY SEAGVTFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLUD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GLUD2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 73 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Male infertility with azoospermia or oligozoospermia due to single gene mutation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0.03

gnomAD missense Z

0.83

DepMap mean gene effect

0.19

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glutamate biosynthetic process
• glutamate metabolic process
• L-glutamate catabolic process

Molecular functions

• ADP binding
• glutamate dehydrogenase (NAD+) activity
• glutamate dehydrogenase (NADP+) activity
• glutamate dehydrogenase [NAD(P)+] activity
• GTP binding
• L-leucine binding

Cellular components

• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase
• Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal
• Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain
• Leu/Phe/Val dehydrogenases active site
• NAD(P) binding domain of glutamate dehydrogenase
• NAD(P)-binding domain superfamily
• Aminoacid dehydrogenase-like, N-terminal domain superfamily
• Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
• Glu/Leu/Phe/Val dehydrogenase, dimerisation domain

KeywordsUniProt

• ADP-ribosylation
• Mitochondrion
• NADP
• Oxidoreductase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of GLUD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GLUD1