Seroatlas · Human Serome Atlas

SDR42E2

Putative short-chain dehydrogenase/reductase family 42E member 2

Also known as: D42E2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKP2
Gene: SDR42E2
Ensembl: ENSG00000183921
Chromosome: 16
Canonical length: 422 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>A6NKP2|SDR42E2
     1  MKSNPPRSSL EACKAAGQAP QQKTQAKPTK AARQKVLVTG GGGYLGFSLG SHLAKSGTSV
    61  ILLDRRRPQW ELSPETKFIQ ADVRDEEALY RAFEGVDCVF HVASYGMSGA EKLQKEQIES
   121  INVGGTKLVI DVCVRRRVPR LIYTSTVNVA FGGKPIEQGD EDSVPYFPLD EHVDHYSRTK
   181  AIADQLTLMA NGMPLPGGGT LRTCVLRPPG IYGPEEQRHL PRVAGHIKKR LFMFRFGDHK
   241  ARMNWVHVHN LVQAHVLAAE ALTTAKGYVA SGQAYYINDG ESVNLFEWMA PLFEKLGYSQ
   301  PWIQVPTSWV YLTAAVMERL HLALRPICSL PPLLTRSEVR SVAVTHTFQI AKARAQLGYA
   361  PDKFRFADAV ELYVQSTTRR PRGSTARTLL RLLLRLLLFL GLLALALHFL GLQPLHAAVE
   421  RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDR42E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

testis: 1.7 nTPM
fallopian tube: 1.2 nTPM
bone marrow: 1.1 nTPM
choroid plexus: 0.9 nTPM
pituitary gland: 0.9 nTPM
basal ganglia: 0.8 nTPM

Single-cell type

ependymal cells: 57 nCPM
choroid plexus epithelial cells: 11 nCPM
astrocytes: 4.8 nCPM
brain excitatory neurons: 2.6 nCPM
brain inhibitory neurons: 2.1 nCPM
other brain neurons: 2.1 nCPM

Immune cell

neutrophil: 5.3 nTPM
classical monocyte: 0.8 nTPM
naive B-cell: 0.7 nTPM
memory B-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

midbrain: 7.1 nTPM
cerebellum: 6.5 nTPM
choroid plexus: 5.5 nTPM
white matter: 5.5 nTPM
cerebral cortex: 4.8 nTPM
hypothalamus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 1.19

OntologyGO

Biological processes

steroid biosynthetic process

Molecular functions

NAD or NADP as acceptor
oxidoreductase activity
acting on the CH-OH group of donors

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDR42E2 as an antibody target. Whether an autoantibody or antibody against SDR42E2 could matter depends on whether native SDR42E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDR42E2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDR42E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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