MAT2B

Protein identityUniProt · HPA

UniProt accession

Q9NZL9

Gene

MAT2B

Ensembl

ENSG00000038274

Chromosome

5

Canonical length

334 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane

Quaternary structure

Homotetramer

OverviewNCBI Gene

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9NZL9|MAT2B
     1  MVGREKELSI HFVPGSCRLV EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ NNWHAVGCGF
    61  RRARPKFEQV NLLDSNAVHH IIHDFQPHVI VHCAAERRPD VVENQPDAAS QLNVDASGNL
   121  AKEAAAVGAF LIYISSDYVF DGTNPPYREE DIPAPLNLYG KTKLDGEKAV LENNLGAAVL
   181  RIPILYGEVE KLEESAVTVM FDKVQFSNKS ANMDHWQQRF PTHVKDVATV CRQLAEKRML
   241  DPSIKGTFHW SGNEQMTKYE MACAIADAFN LPSSHLRPIT DSPVLGAQRP RNAQLDCSKL
   301  ETLGIGQRTP FRIGIKESLW PFLIDKRWRQ TVFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAT2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

100 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.68

gnomAD pLI

0.05

gnomAD missense Z

1.07

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• one-carbon metabolic process
• S-adenosylmethionine biosynthetic process

Molecular functions

• enzyme binding
• enzyme regulator activity
• methionine adenosyltransferase regulator activity

Cellular components

• cytosol
• extracellular exosome
• methionine adenosyltransferase complex
• nucleus

Protein domainsUniProt · Pfam · InterPro

• NAD(P)-binding domain superfamily
• dTDP-4-dehydrorhamnose reductase
• RmlD-like, substrate binding domain
• RmlD substrate binding domain

KeywordsUniProt

• NADP
• One-carbon metabolism
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of MAT2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAT2A