Seroatlas · Human Serome Atlas

CBR1

Carbonyl reductase [NADPH] 1

Also known as: CBR, CBR1_HUMAN, SDR21C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16152
Gene
CBR1
Ensembl
ENSG00000159228
Chromosome
21
Canonical length
277 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>P16152|CBR1
     1  MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH
    61  QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD
   121  VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK
   181  KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA
   241  TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
549 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 549 nTPM
  • choroid plexus: 379 nTPM
  • small intestine: 326 nTPM
  • liver: 236 nTPM
  • spinal cord: 227 nTPM
  • basal ganglia: 201 nTPM

Single-cell type

  • enterocytes: 1,118 nCPM
  • esophageal basal cells: 684 nCPM
  • esophageal suprabasal cells: 458 nCPM
  • suprabasal keratinocytes: 356 nCPM
  • basal keratinocytes: 322 nCPM
  • hepatocytes: 321 nCPM

Immune cell

  • intermediate monocyte: 199 nTPM
  • total PBMC: 162 nTPM
  • non-classical monocyte: 158 nTPM
  • classical monocyte: 134 nTPM
  • myeloid DC: 110 nTPM
  • naive CD4 T-cell: 103 nTPM

Brain region

  • white matter: 356 nTPM
  • choroid plexus: 249 nTPM
  • basal ganglia: 226 nTPM
  • cerebellum: 202 nTPM
  • thalamus: 188 nTPM
  • cerebral cortex: 182 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBR1 as an antibody target. Whether an autoantibody or antibody against CBR1 could matter depends on whether native CBR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CBR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CBR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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