Seroatlas · Human Serome Atlas

SCCPDH

Saccharopine dehydrogenase-like oxidoreductase

Also known as: CGI-49, NET11, SCPDL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBX0
Gene: SCCPDH
Ensembl: ENSG00000143653
Chromosome: 1
Canonical length: 429 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Located in lipid droplet and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q8NBX0|SCCPDH
     1  MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE KLQRVLEKAA
    61  LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG PYRFYGEPVI KACIENGASC
   121  IDISGEPQFL ELMQLKYHEK AADKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF
   181  LTIHSGPEGL SIHDGTWKSA IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE
   241  LKGYSIPFMG SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV
   301  RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG TDKNKPNIKI
   361  CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT PGAAFSKTKL IDRLNKHGIE
   421  FSVISSSEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCCPDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 150 nTPM
testis: 149 nTPM
liver: 148 nTPM
urinary bladder: 76 nTPM
midbrain: 57 nTPM
skeletal muscle: 57 nTPM

Single-cell type

late primary spermatocytes: 2,112 nCPM
early spermatids: 1,241 nCPM
urothelial cells: 371 nCPM
prostatic club cells: 321 nCPM
oocytes: 290 nCPM
hepatocytes: 240 nCPM

Immune cell

basophil: 875 nTPM
eosinophil: 44 nTPM
NK-cell: 34 nTPM
classical monocyte: 24 nTPM
MAIT T-cell: 22 nTPM
intermediate monocyte: 22 nTPM

Brain region

white matter: 143 nTPM
medulla oblongata: 98 nTPM
spinal cord: 82 nTPM
pons: 74 nTPM
cerebellum: 71 nTPM
thalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glycolipid biosynthetic process

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Saccharopine dehydrogenase, NADP binding domain
NAD(P)-binding domain superfamily
Saccharopine dehydrogenase NADP binding domain
Saccharopine dehydrogenase-like oxidoreductase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCCPDH as an antibody target. Whether an autoantibody or antibody against SCCPDH could matter depends on whether native SCCPDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCCPDH is annotated as secreted, so native SCCPDH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCCPDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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