Seroatlas · Human Serome Atlas

BLVRA

Biliverdin reductase A

Also known as: BIEA_HUMAN, BLVR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53004
Gene
BLVRA
Ensembl
ENSG00000106605
Chromosome
7
Canonical length
296 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>P53004|BLVRA
     1  MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE
    61  DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV
   121  LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF
   181  GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN
   241  VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLVRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 123 nTPM
  • spleen: 77 nTPM
  • tongue: 65 nTPM
  • esophagus: 65 nTPM
  • bone marrow: 62 nTPM
  • lung: 59 nTPM

Single-cell type

  • epididymal principal cells: 621 nCPM
  • hofbauer cells: 481 nCPM
  • esophageal apical cells: 376 nCPM
  • kupffer cells: 212 nCPM
  • esophageal suprabasal cells: 156 nCPM
  • mast cells: 135 nCPM

Immune cell

  • intermediate monocyte: 375 nTPM
  • non-classical monocyte: 370 nTPM
  • classical monocyte: 293 nTPM
  • total PBMC: 208 nTPM
  • eosinophil: 170 nTPM
  • myeloid DC: 136 nTPM

Brain region

  • hypothalamus: 30 nTPM
  • pons: 29 nTPM
  • thalamus: 29 nTPM
  • midbrain: 28 nTPM
  • medulla oblongata: 27 nTPM
  • spinal cord: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BLVRA.

Disease | AllUniProt

Conditions BLVRA is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hyperbiliverdinemia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLVRA as an antibody target. Whether an autoantibody or antibody against BLVRA could matter depends on whether native BLVRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLVRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BLVRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BLVRA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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