Seroatlas · Human Serome Atlas

RDH8

Retinol dehydrogenase 8

Also known as: PRRDH, RDH8_HUMAN, SDR28C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYR8
Gene
RDH8
Ensembl
ENSG00000080511
Chromosome
19
Canonical length
311 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Midbody ring,Cytosol

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q9NYR8|RDH8
     1  MAAAPRTVLI SGCSSGIGLE LAVQLAHDPK KRYQVVATMR DLGKKETLEA AAGEALGQTL
    61  TVAQLDVCSD ESVAQCLSCI QGEVDVLVNN AGMGLVGPLE GLSLAAMQNV FDTNFFGAVR
   121  LVKAVLPGMK RRRQGHIVVI SSVMGLQGVI FNDVYAASKF ALEGFFESLA IQLLQFNIFI
   181  SLVEPGPVVT EFEGKLLAQV SMAEFPGTDP ETLHYFRDLY LPASRKLFCS VGQNPQDVVQ
   241  AIVNVISSTR PPLRRQTNIR YSPLTTLKTV DSSGSLYVRT THRLLFRCPR LLNLGLQCLS
   301  CGCLPTRVRP R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • retina: 106 nTPM
  • kidney: 3.8 nTPM
  • testis: 3 nTPM
  • parathyroid gland: 0.2 nTPM
  • appendix: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • rod photoreceptor cells: 164 nCPM
  • early spermatids: 61 nCPM
  • loop of henle epithelial cells: 52 nCPM
  • cone photoreceptor cells: 48 nCPM
  • late primary spermatocytes: 43 nCPM
  • retinal bipolar cells: 25 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.2 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RDH8.

Disease | AllUniProt

Conditions RDH8 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 32 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDH8 as an antibody target. Whether an autoantibody or antibody against RDH8 could matter depends on whether native RDH8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDH8 is annotated at the cell surface, where native RDH8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RDH8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RDH8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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