Seroatlas · Human Serome Atlas

GFOD1

Glucose-fructose oxidoreductase domain-containing protein 1

Also known as: ADG-90, C6orf114, FLJ20330, GFOD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXC2
Gene: GFOD1
Ensembl: ENSG00000145990
Chromosome: 6
Canonical length: 390 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Secretome location: Secreted - unknown location
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q9NXC2|GFOD1
     1  MLPGVGVFGT SLTARVIIPL LKDEGFAVKA LWGRTQEEAE ELAKEMSVPF YTSRIDEVLL
    61  HQDVDLVCIN LPPPLTRQIA VKTLGIGKNV ICDRTATPLD AFRMTSAAHY YPKLMSIMGN
   121  VLRFLPAFVR MKQLIEEGYV GEPLVCEVQV HGGSLLGKKY NWSCDDLMGG GGLHSVGTYI
   181  IDLLTFLTGQ KAVKVHGLLK TFVKQTDHIK GIRQITSDDF CTFQMVLEGG VCCTVTLNFN
   241  VPGEFKQDVT VVGSAGRLLA VGTDLYGQRN SAPEQELLVQ DATPVSNSLL PEKAFSDIPS
   301  PYLRGTIKMM QAVRQAFQDQ DDRRTWDGRP LTMAATFDDC LYALCVVDTI KRSSQTGEWQ
   361  NIAIMTEEPE LSPAYLISEA MRRSRMSLYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GFOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 22 nTPM
cerebral cortex: 18 nTPM
heart muscle: 15 nTPM
blood vessel: 15 nTPM
bone marrow: 12 nTPM
hippocampal formation: 12 nTPM

Single-cell type

nk-cells: 298 nCPM
vascular endothelial cells: 220 nCPM
brain excitatory neurons: 196 nCPM
neutrophil progenitors: 186 nCPM
corticotrophs: 164 nCPM
cardiomyocytes: 151 nCPM

Immune cell

eosinophil: 16 nTPM
NK-cell: 13 nTPM
memory B-cell: 2.7 nTPM
naive B-cell: 1.9 nTPM
gdT-cell: 1.5 nTPM
total PBMC: 1 nTPM

Brain region

cerebral cortex: 87 nTPM
hippocampal formation: 85 nTPM
basal ganglia: 70 nTPM
white matter: 67 nTPM
amygdala: 57 nTPM
cerebellum: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.05
gnomAD missense Z: 2.64
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GFOD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NKIRAS2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GFOD1 as an antibody target. Whether an autoantibody or antibody against GFOD1 could matter depends on whether native GFOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GFOD1 is annotated as secreted, so native GFOD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GFOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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