Seroatlas · Human Serome Atlas

CRYZL1

Quinone oxidoreductase-like protein 1

Also known as: 4P11, QOH-1, QORL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95825
Gene: CRYZL1
Ensembl: ENSG00000205758
Chromosome: 21
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>O95825|CRYZL1
     1  MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF
    61  PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT
   121  EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE
   181  DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ
   241  LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
   301  LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYZL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 38 nTPM
cerebral cortex: 35 nTPM
amygdala: 34 nTPM
midbrain: 32 nTPM
testis: 32 nTPM
spinal cord: 29 nTPM

Single-cell type

late primary spermatocytes: 71 nCPM
early spermatids: 28 nCPM
migrating cytotrophoblasts: 15 nCPM
cytotrophoblasts: 15 nCPM
gastric chief cells: 14 nCPM
parietal cells: 12 nCPM

Immune cell

NK-cell: 47 nTPM
myeloid DC: 43 nTPM
naive CD4 T-cell: 43 nTPM
naive B-cell: 40 nTPM
memory B-cell: 38 nTPM
intermediate monocyte: 38 nTPM

Brain region

white matter: 80 nTPM
cerebellum: 79 nTPM
midbrain: 72 nTPM
hypothalamus: 69 nTPM
basal ganglia: 68 nTPM
cerebral cortex: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Endosome

InteractionsUniProt · HPA

Protein binding partners of CRYZL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1R21

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYZL1 as an antibody target. Whether an autoantibody or antibody against CRYZL1 could matter depends on whether native CRYZL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYZL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYZL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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