Seroatlas · Human Serome Atlas

DCXR

L-xylulose reductase

Also known as: DCR, DCXR_HUMAN, HCR2, KIDCR, P34H, SDR20C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4W1
Gene
DCXR
Ensembl
ENSG00000169738
Chromosome
17
Canonical length
244 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Microtubules
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q7Z4W1|DCXR
     1  MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD
    61  LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR
   121  GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT
   181  VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG
   241  FWAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCXR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
1,924 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,924 nTPM
  • epididymis: 265 nTPM
  • kidney: 224 nTPM
  • skeletal muscle: 191 nTPM
  • stomach: 169 nTPM
  • midbrain: 147 nTPM

Single-cell type

  • hepatocytes: 4,222 nCPM
  • epididymal principal cells: 1,490 nCPM
  • breast lactating cells: 1,054 nCPM
  • epididymal efferent duct absorptive cells: 674 nCPM
  • extravillous trophoblasts: 620 nCPM
  • parietal cells: 534 nCPM

Immune cell

  • myeloid DC: 152 nTPM
  • plasmacytoid DC: 122 nTPM
  • naive CD4 T-cell: 118 nTPM
  • total PBMC: 110 nTPM
  • NK-cell: 109 nTPM
  • naive B-cell: 100 nTPM

Brain region

  • thalamus: 103 nTPM
  • pons: 100 nTPM
  • cerebellum: 93 nTPM
  • hypothalamus: 90 nTPM
  • medulla oblongata: 88 nTPM
  • midbrain: 85 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCXR.

Disease | AllUniProt

Conditions DCXR is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 49 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Essential pentosuria
  • DCXR-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCXR as an antibody target. Whether an autoantibody or antibody against DCXR could matter depends on whether native DCXR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCXR is annotated at the cell surface, where native DCXR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DCXR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCXR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...