CTBP2
C-terminal-binding protein 2
Also known as: CTBP2_HUMAN, ribeye
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P56545
- Gene
- CTBP2
- Ensembl
- ENSG00000175029
- Chromosome
- 10
- Canonical length
- 445 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Canonical amino-acid sequenceUniProt
445 residues, UniProt reviewed canonical sequence.
>P56545|CTBP2
1 MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC
61 DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG
121 IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG
181 ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS
241 LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES
301 EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE
361 FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV
421 AHPSQAPSPN QPTKHGDNRE HPNEQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CTBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 60 nTPM
Expression across tissuesHPA
Tissue
- retina: 60 nTPM
- thyroid gland: 59 nTPM
- cervix: 49 nTPM
- blood vessel: 46 nTPM
- endometrium: 44 nTPM
- choroid plexus: 42 nTPM
Single-cell type
- endometrial glandular cells: 998 nCPM
- endometrial luminal cells: 864 nCPM
- endometrial ciliated cells: 600 nCPM
- neutrophils: 506 nCPM
- pituicytes/fscs: 504 nCPM
- retinal amacrine cells: 494 nCPM
Immune cell
- NK-cell: 35 nTPM
- basophil: 32 nTPM
- non-classical monocyte: 23 nTPM
- eosinophil: 16 nTPM
- neutrophil: 15 nTPM
- myeloid DC: 11 nTPM
Brain region
- choroid plexus: 100 nTPM
- cerebellum: 67 nTPM
- hypothalamus: 58 nTPM
- medulla oblongata: 49 nTPM
- thalamus: 49 nTPM
- midbrain: 49 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CTBP2.
Disease | GeneticClinVar
3 pathogenic / likely-pathogenic of 71 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.53
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.06
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of cell population proliferation
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- positive regulation of retinoic acid receptor signaling pathway
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- viral genome replication
- white fat cell differentiation
Molecular functions
- DNA-binding transcription factor binding
- identical protein binding
- NAD binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- protein kinase binding
- protein-containing complex binding
- transcription coactivator activity
- transcription coregulator binding
- transcription corepressor activity
- transcription corepressor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
- NAD(P)-binding domain superfamily
- C-terminal binding protein
- C-terminal-binding dehydrogenase
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CTBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CTBP2 as an antibody target. Whether an autoantibody or antibody against CTBP2 could matter depends on whether native CTBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CTBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CTBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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