Seroatlas · Human Serome Atlas

GRHPR

Glyoxylate reductase/hydroxypyruvate reductase

Also known as: GLXR, GRHPR_HUMAN, PH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBQ7
Gene
GRHPR
Ensembl
ENSG00000137106
Chromosome
9
Canonical length
328 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q9UBQ7|GRHPR
     1  MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS
    61  DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL
   121  TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF
   181  LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF
   241  INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR
   301  TRNTMSLLAA NNLLAGLRGE PMPSELKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRHPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
610 nTPM

Expression across tissuesHPA

Tissue

  • liver: 610 nTPM
  • skeletal muscle: 158 nTPM
  • kidney: 146 nTPM
  • adrenal gland: 141 nTPM
  • tongue: 137 nTPM
  • choroid plexus: 107 nTPM

Single-cell type

  • hepatocytes: 1,048 nCPM
  • esophageal suprabasal cells: 209 nCPM
  • oocytes: 203 nCPM
  • epididymal principal cells: 196 nCPM
  • decidual stromal cells: 193 nCPM
  • cytotrophoblasts: 185 nCPM

Immune cell

  • myeloid DC: 70 nTPM
  • intermediate monocyte: 67 nTPM
  • naive B-cell: 66 nTPM
  • classical monocyte: 65 nTPM
  • NK-cell: 65 nTPM
  • plasmacytoid DC: 64 nTPM

Brain region

  • white matter: 94 nTPM
  • cerebellum: 86 nTPM
  • basal ganglia: 85 nTPM
  • thalamus: 74 nTPM
  • medulla oblongata: 72 nTPM
  • hypothalamus: 70 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRHPR.

Disease | AllUniProt

Conditions GRHPR is implicated in, by any mechanism.

Disease | GeneticClinVar

166 pathogenic / likely-pathogenic of 638 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRHPR as an antibody target. Whether an autoantibody or antibody against GRHPR could matter depends on whether native GRHPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRHPR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRHPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRHPR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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