LDHC
L-lactate dehydrogenase C chain
Also known as: CT32, LDHC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P07864
- Gene
- LDHC
- Ensembl
- ENSG00000166796
- Chromosome
- 11
- Canonical length
- 332 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol,Mid piece,Principal piece,End piece
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
332 residues, UniProt reviewed canonical sequence.
>P07864|LDHC
1 MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG
61 EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI
121 IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV
181 HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE
241 IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV
301 SDVVKINLNS EEEALFKKSA ETLWNIQKDL IFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LDHC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 248 nTPM
Expression across tissuesHPA
Tissue
- testis: 248 nTPM
- liver: 1.3 nTPM
- pancreas: 1.2 nTPM
- kidney: 0.7 nTPM
- small intestine: 0.7 nTPM
- skeletal muscle: 0.6 nTPM
Single-cell type
- late primary spermatocytes: 4,061 nCPM
- early spermatids: 1,060 nCPM
- early primary spermatocytes: 373 nCPM
- late spermatids: 115 nCPM
- endometrial luminal cells: 47 nCPM
- breast myoepithelial cells: 41 nCPM
Immune cell
- neutrophil: 1.1 nTPM
- naive CD4 T-cell: 1 nTPM
- plasmacytoid DC: 0.9 nTPM
- naive B-cell: 0.7 nTPM
- naive CD8 T-cell: 0.7 nTPM
- basophil: 0.6 nTPM
Brain region
- cerebellum: 4.1 nTPM
- cerebral cortex: 3.9 nTPM
- hippocampal formation: 3.5 nTPM
- basal ganglia: 3.3 nTPM
- amygdala: 3.2 nTPM
- choroid plexus: 3.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- ATP biosynthetic process
- flagellated sperm motility
- lactate biosynthetic process from pyruvate
- lactate metabolic process
- pyruvate catabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Lactate/malate dehydrogenase, N-terminal
- L-lactate/malate dehydrogenase
- L-lactate dehydrogenase
- Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
- L-lactate dehydrogenase, active site
- Lactate/malate dehydrogenase, C-terminal
- NAD(P)-binding domain superfamily
- lactate/malate dehydrogenase, NAD binding domain
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LDHC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LDHC as an antibody target. Whether an autoantibody or antibody against LDHC could matter depends on whether native LDHC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LDHC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LDHC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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