NOXRED1
NADP-dependent oxidoreductase domain-containing protein 1
Also known as: C14orf148, FLJ32809, NXRD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6NXP6
- Gene
- NOXRED1
- Ensembl
- ENSG00000165555
- Chromosome
- 14
- Canonical length
- 359 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
359 residues, UniProt reviewed canonical sequence.
>Q6NXP6|NOXRED1
1 MDMLQDLESL QFEYGVPEED RIWLYLQGRS RGLMIEACAH ATFFCKLLYN LRASLNKNQS
61 SRHLSIGSLN SATPEEFKVG IIGGGHLGKQ LAGTLLQLGP IPAESLRIST RRPETLGELQ
121 KLGIKCFYHN ADLVSWADVI FLCCLPSQLP NICVEIYTSL EKASIVYSFV AAIPLPRLKL
181 LLNHTNILRP QYQYDEDSVS VWGANKGVIA ALQDPTILQA TCPYSPAGGI ILNIKWLEGV
241 FYAALNICTA RNMAHSQVLQ LLSELFLSVH FEDCGKDTAS CPKLQLTDFV SKAYGKNLSQ
301 ERPFPWFDLT AVQLKETPFS QHLSSSPVLQ DHLTHLYCAS FGISLTKEQP VISTGFPSQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NOXRED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 5.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.7 nTPM
- retina: 4 nTPM
- pituitary gland: 0.6 nTPM
- thyroid gland: 0.6 nTPM
- skin: 0.5 nTPM
- adrenal gland: 0.4 nTPM
Single-cell type
- late spermatids: 182 nCPM
- early spermatids: 153 nCPM
- late primary spermatocytes: 77 nCPM
- cone photoreceptor cells: 33 nCPM
- sertoli cells: 33 nCPM
- rod photoreceptor cells: 30 nCPM
Immune cell
- eosinophil: 0.5 nTPM
- T-reg: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 3.4 nTPM
- medulla oblongata: 2 nTPM
- midbrain: 2 nTPM
- spinal cord: 1.9 nTPM
- basal ganglia: 1.4 nTPM
- hypothalamus: 1.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.02
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NOXRED1 as an antibody target. Whether an autoantibody or antibody against NOXRED1 could matter depends on whether native NOXRED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NOXRED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NOXRED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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