Seroatlas · Human Serome Atlas

HPGD

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Also known as: PGDH_HUMAN, SDR36C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P15428
Gene: HPGD
Ensembl: ENSG00000164120
Chromosome: 4
Canonical length: 266 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P15428|HPGD
     1  MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF
    61  IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD
   121  YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA
   181  ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG
   241  AIMKITTSKG IHFQDYDTTP FQAKTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPGD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 352 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 352 nTPM
stomach: 222 nTPM
liver: 197 nTPM
breast: 151 nTPM
duodenum: 143 nTPM
small intestine: 111 nTPM

Single-cell type

esophageal apical cells: 2,509 nCPM
urothelial cells: 1,576 nCPM
mast cells: 1,379 nCPM
extravillous trophoblasts: 1,375 nCPM
foveolar cells: 1,122 nCPM
neutrophils: 640 nCPM

Immune cell

basophil: 124 nTPM
T-reg: 45 nTPM
eosinophil: 17 nTPM
MAIT T-cell: 16 nTPM
gdT-cell: 10 nTPM
memory CD4 T-cell: 5.2 nTPM

Brain region

choroid plexus: 17 nTPM
hypothalamus: 5.5 nTPM
midbrain: 3.7 nTPM
medulla oblongata: 2.3 nTPM
cerebral cortex: 2 nTPM
hippocampal formation: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HPGD.

Disease | AllUniProt

Conditions HPGD is implicated in, by any mechanism.

Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) MIM:259100
Cranioosteoarthropathy (COA) MIM:259100
Digital clubbing, isolated congenital (DIGC) MIM:119900

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 205 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypertrophic osteoarthropathy, primary, autosomal recessive, 1
Isolated congenital digital clubbing
Cranioosteoarthropathy
HPGD-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

15-hydroxyprostaglandin dehydrogenase (NAD+) activity
identical protein binding
NAD binding
NAD+ binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
prostaglandin E receptor activity
15-hydroxyicosatetraenoate dehydrogenase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HPGD as an antibody target. Whether an autoantibody or antibody against HPGD could matter depends on whether native HPGD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HPGD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HPGD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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