Seroatlas · Human Serome Atlas

LDHAL6B

L-lactate dehydrogenase A-like 6B

Also known as: LDH6B, LDH6B_HUMAN, LDHAL6, LDHL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYZ2
Gene: LDHAL6B
Ensembl: ENSG00000171989
Chromosome: 15
Canonical length: 381 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable L-lactate dehydrogenase activity. Involved in lactate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q9BYZ2|LDHAL6B
     1  MSWTVPVVRA SQRVSSVGAN FLCLGMALCP RQATRIPLNG TWLFTPVSKM ATVKSELIER
    61  FTSEKPVHHS KVSIIGTGSV GMACAISILL KGLSDELALV DLDEDKLKGE TMDLQHGSPF
   121  TKMPNIVCSK DYFVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMI SSIVQYSPHC
   181  KLIIVSNPVD ILTYVAWKLS AFPKNRIIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG
   241  EHGDSSVPVW SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH KEVTATAYEI IKMKGYTSWA
   301  IGLSVADLTE SILKNLRRIH PVSTIIKGLY GIDEEVFLSI PCILGENGIT NLIKIKLTPE
   361  EEAHLKKSAK TLWEIQNKLK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDHAL6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
adipose tissue: 0.3 nTPM
blood vessel: 0.3 nTPM
liver: 0.3 nTPM
small intestine: 0.3 nTPM
breast: 0.2 nTPM

Single-cell type

late primary spermatocytes: 197 nCPM
early primary spermatocytes: 60 nCPM
late spermatids: 6.3 nCPM
early spermatids: 4.3 nCPM
peritubular myoid cells: 1.2 nCPM
sertoli cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 5.8 nTPM
white matter: 4.7 nTPM
medulla oblongata: 3.5 nTPM
thalamus: 3.2 nTPM
pons: 3.1 nTPM
basal ganglia: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0.07
gnomAD missense Z: -1.09
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

L-lactate dehydrogenase (NAD+) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LDHAL6B as an antibody target. Whether an autoantibody or antibody against LDHAL6B could matter depends on whether native LDHAL6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LDHAL6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LDHAL6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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