Seroatlas · Human Serome Atlas

DHRS3

Short-chain dehydrogenase/reductase 3

Also known as: DHRS3_HUMAN, RDH17, retSDR1, Rsdr1, SDR1, SDR16C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75911
Gene
DHRS3
Ensembl
ENSG00000162496
Chromosome
1
Canonical length
302 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>O75911|DHRS3
     1  MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI GRQLAREFAE
    61  RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR EEVYQTAKAV REKVGDITIL
   121  VNNAAVVHGK SLMDSDDDAL LKSQHINTLG QFWTTKAFLP RMLELQNGHI VCLNSVLALS
   181  AIPGAIDYCT SKASAFAFME SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP
   241  LKPETVARRT VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG
   301  RT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
238 nTPM

Expression across tissuesHPA

Tissue

  • liver: 238 nTPM
  • choroid plexus: 165 nTPM
  • prostate: 128 nTPM
  • adipose tissue: 112 nTPM
  • thyroid gland: 91 nTPM
  • esophagus: 89 nTPM

Single-cell type

  • prostatic hillock cells: 645 nCPM
  • esophageal apical cells: 595 nCPM
  • late spermatids: 561 nCPM
  • podocytes: 549 nCPM
  • salivary duct cells: 421 nCPM
  • basal prostatic cells: 365 nCPM

Immune cell

  • gdT-cell: 87 nTPM
  • naive CD4 T-cell: 79 nTPM
  • MAIT T-cell: 63 nTPM
  • naive CD8 T-cell: 50 nTPM
  • total PBMC: 48 nTPM
  • memory CD4 T-cell: 47 nTPM

Brain region

  • choroid plexus: 163 nTPM
  • medulla oblongata: 82 nTPM
  • white matter: 53 nTPM
  • thalamus: 49 nTPM
  • spinal cord: 47 nTPM
  • hypothalamus: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DHRS3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 67 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • DHRS3 Deficiency
  • Craniosynostosis-scoliosis syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.23
gnomAD missense Z
1.48
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS3 as an antibody target. Whether an autoantibody or antibody against DHRS3 could matter depends on whether native DHRS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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