Seroatlas · Human Serome Atlas

HSD17B8

(3R)-3-hydroxyacyl-CoA dehydrogenase

Also known as: D6S2245E, DHB8_HUMAN, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92506
Gene: HSD17B8
Ensembl: ENSG00000204228
Chromosome: 6
Canonical length: 261 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q92506|HSD17B8
     1  MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS
    61  KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW
   121  DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT
   181  QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL
   241  ASEDSGYITG TSVEVTGGLF M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

liver: 63 nTPM
pancreas: 54 nTPM
parathyroid gland: 40 nTPM
kidney: 34 nTPM
thyroid gland: 31 nTPM
epididymis: 28 nTPM

Single-cell type

hepatocytes: 78 nCPM
esophageal suprabasal cells: 62 nCPM
epididymal efferent duct absorptive cells: 60 nCPM
plasma cells: 59 nCPM
enterocytes: 56 nCPM
epididymal efferent duct ciliated cells: 54 nCPM

Immune cell

MAIT T-cell: 30 nTPM
memory CD8 T-cell: 29 nTPM
naive CD8 T-cell: 29 nTPM
total PBMC: 27 nTPM
naive CD4 T-cell: 27 nTPM
memory CD4 T-cell: 24 nTPM

Brain region

medulla oblongata: 11 nTPM
midbrain: 9.6 nTPM
spinal cord: 8.3 nTPM
white matter: 7.9 nTPM
thalamus: 7.6 nTPM
choroid plexus: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B8 as an antibody target. Whether an autoantibody or antibody against HSD17B8 could matter depends on whether native HSD17B8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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