Seroatlas · Human Serome Atlas

DHRS2

Dehydrogenase/reductase SDR family member 2, mitochondrial

Also known as: DHRS2_HUMAN, HEP27, SDR25C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13268
Gene
DHRS2
Ensembl
ENSG00000100867
Chromosome
14
Canonical length
280 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q13268|DHRS2
     1  MLSAVARGYQ GWFHPCARLS VRMSSTGIDR KGVLANRVAV VTGSTSGIGF AIARRLARDG
    61  AHVVISSRKQ QNVDRAMAKL QGEGLSVAGI VCHVGKAEDR EQLVAKALEH CGGVDFLVCS
   121  AGVNPLVGST LGTSEQIWDK ILSVNVKSPA LLLSQLLPYM ENRRGAVILV SSIAAYNPVV
   181  ALGVYNVSKT ALLGLTRTLA LELAPKDIRV NCVVPGIIKT DFSKVFHGNE SLWKNFKEHH
   241  QLQRIGESED CAGIVSFLCS PDASYVNGEN IAVAGYSTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
418 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 418 nTPM
  • breast: 316 nTPM
  • salivary gland: 92 nTPM
  • ovary: 90 nTPM
  • liver: 26 nTPM
  • spleen: 18 nTPM

Single-cell type

  • urothelial cells: 3,414 nCPM
  • prostatic club cells: 558 nCPM
  • prostatic hillock cells: 465 nCPM
  • papillary tip epithelial cells: 325 nCPM
  • ovarian stromal cells: 53 nCPM
  • pancreatic acinar cells: 35 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 3.2 nTPM
  • hypothalamus: 2 nTPM
  • midbrain: 2 nTPM
  • hippocampal formation: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • cerebral cortex: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DHRS2.

Disease | ImmuneIEDB

Conditions an epitope on DHRS2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
-1.17
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DHRS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS2 as an antibody target. Whether an autoantibody or antibody against DHRS2 could matter depends on whether native DHRS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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