Seroatlas · Human Serome Atlas

DHRS1

Dehydrogenase/reductase SDR family member 1

Also known as: DHRS1_HUMAN, FLJ25430, MGC20204, SDR19C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LJ7
Gene: DHRS1
Ensembl: ENSG00000157379
Chromosome: 14
Canonical length: 313 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q96LJ7|DHRS1
     1  MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE AQSLGGQCVP
    61  VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI LNTRNKAFWE TPASMWDDIN
   121  NVGLRGHYFC SVYGARLMVP AGQGLIVVIS SPGSLQYMFN VPYGVGKAAC DKLAADCAHE
   181  LRRHGVSCVS LWPGIVQTEL LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA
   241  TDPNILSLSG KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR
   301  VPKWIIALYT SKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

esophagus: 70 nTPM
liver: 59 nTPM
skin: 42 nTPM
cervix: 27 nTPM
salivary gland: 27 nTPM
vagina: 26 nTPM

Single-cell type

late spermatids: 23 nCPM
esophageal apical cells: 20 nCPM
oligodendrocytes: 18 nCPM
suprabasal keratinocytes: 17 nCPM
microglia: 17 nCPM
bergmann glia: 16 nCPM

Immune cell

eosinophil: 18 nTPM
basophil: 15 nTPM
T-reg: 12 nTPM
myeloid DC: 11 nTPM
intermediate monocyte: 10 nTPM
memory B-cell: 9.9 nTPM

Brain region

white matter: 3.1 nTPM
choroid plexus: 3 nTPM
hypothalamus: 2.6 nTPM
medulla oblongata: 2.6 nTPM
cerebellum: 2.1 nTPM
pons: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbonyl reductase (NADPH) activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
testosterone dehydrogenase (NADP+) activity
estradiol 17-alpha-dehydrogenase [NAD(P)+] activity

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS1 as an antibody target. Whether an autoantibody or antibody against DHRS1 could matter depends on whether native DHRS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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