Seroatlas · Protein domains

C2 domain

IPR000008

Definition

The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies of the C1 domain in Protein Kinase C and the protein kinase catalytic domain PMID:22453964. Regions with significant homology PMID:7559667 to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding PMID:8253763 and in membrane targetting processes such as subcellular localisation. The 3D structure of the C2 domain of synaptotagmin has been reported PMID:7697723, the domain forms an eight-stranded β-sandwich constructed around a conserved 4-stranded motif, designated a C2 key PMID:7697723. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel β-sandwich.

146 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (146 proteins: gene, accession, name)

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