Seroatlas · Human Serome Atlas

CPNE2

Copine-2

Also known as: CPN2, CPNE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FN4
Gene
CPNE2
Ensembl
ENSG00000140848
Chromosome
16
Canonical length
548 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q96FN4|CPNE2
     1  MAHIPSGGAP AAGAAPMGPQ YCVCKVELSV SGQNLLDRDV TSKSDPFCVL FTENNGRWIE
    61  YDRTETAINN LNPAFSKKFV LDYHFEEVQK LKFALFDQDK SSMRLDEHDF LGQFSCSLGT
   121  IVSSKKITRP LLLLNDKPAG KGLITIAAQE LSDNRVITLS LAGRRLDKKD LFGKSDPFLE
   181  FYKPGDDGKW MLVHRTEVIK YTLDPVWKPF TVPLVSLCDG DMEKPIQVMC YDYDNDGGHD
   241  FIGEFQTSVS QMCEARDSVP LEFECINPKK QRKKKNYKNS GIIILRSCKI NRDYSFLDYI
   301  LGGCQLMFTV GIDFTASNGN PLDPSSLHYI NPMGTNEYLS AIWAVGQIIQ DYDSDKMFPA
   361  LGFGAQLPPD WKVSHEFAIN FNPTNPFCSG VDGIAQAYSA CLPHIRFYGP TNFSPIVNHV
   421  ARFAAQATQQ RTATQYFILL IITDGVISDM EETRHAVVQA SKLPMSIIIV GVGNADFAAM
   481  EFLDGDSRML RSHTGEEAAR DIVQFVPFRE FRNAAKETLA KAVLAELPQQ VVQYFKHKNL
   541  PPTNSEPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 57 nTPM
  • spinal cord: 47 nTPM
  • choroid plexus: 41 nTPM
  • lung: 35 nTPM
  • cervix: 34 nTPM
  • adipose tissue: 33 nTPM

Single-cell type

  • oligodendrocytes: 115 nCPM
  • megakaryocytes: 105 nCPM
  • neutrophil progenitors: 100 nCPM
  • bergmann glia: 95 nCPM
  • ependymal cells: 87 nCPM
  • endometrial luminal cells: 62 nCPM

Immune cell

  • classical monocyte: 1.5 nTPM
  • neutrophil: 1.5 nTPM
  • eosinophil: 0.8 nTPM
  • myeloid DC: 0.8 nTPM
  • intermediate monocyte: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • white matter: 156 nTPM
  • hypothalamus: 106 nTPM
  • medulla oblongata: 91 nTPM
  • basal ganglia: 84 nTPM
  • cerebral cortex: 81 nTPM
  • midbrain: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
1.54
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPNE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE2 as an antibody target. Whether an autoantibody or antibody against CPNE2 could matter depends on whether native CPNE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE2 is annotated at the cell surface, where native CPNE2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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