Seroatlas · Human Serome Atlas

C2CD2

C2 domain-containing protein 2

Also known as: C21orf25, C21orf258, C2CD2_HUMAN, DKFZP586F0422, TMEM24L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y426
Gene: C2CD2
Ensembl: ENSG00000157617
Chromosome: 21
Canonical length: 696 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q9Y426|C2CD2
     1  MAMARLGSWL GEAQWLALVS LFVAALATVG LYLAQWALAR ARPQPQRRAV EPGEGPRPGS
    61  DALLSWILTL GSWRSQWQAA WVTALNEEAE RKGGPPFLSF EEDPRQQALE LVVQEVSSVL
   121  RSAEEKVVVC HVVGQAIQFL VSETPALGAG CRLYDMRLSP FHLQLEFHMK EKREDLQISW
   181  SFISVPEMAV NIQPKALGED QVAETSAMSD VLKDILKHLA GSASPSVVLI TKPTTVKEAQ
   241  NLQCAASTAQ ESCPPKPPRA HELKLLVRNI HVLLLSEPGA SGHINAVCVV QLNDPVQRFS
   301  STLTKNTPDL MWEEEFTFEL NAKSKELHLQ ISEAGRSSEG LLATATVPLD LFKKQPSGPQ
   361  SFTLTSGSAC GSSVLGSVTA EFSYMEPGEL KSWPIPPPVP AAKIEKDRTV MPCGTVVTTV
   421  TAVKTKPRVD VGRASPLSSD SPVKTPIKVK VIEKDISVQA IACRSAPVSK TLSSSDTELL
   481  VLNGSDPVAE VAIRQLSESS KLKLKSPRKK STIIISGISK TSLSQDHDAA LMQGYTASVD
   541  STHQEDAPSH PERAAASAPP EEAESAQASL APKPQEDELD SWDLEKEPQA AAWSSQVLLD
   601  PDGDELSESS MSVLEPGTAK KHKGGILRKG AKLFFRRRHQ QKDPGMSQSH NDLVFLEQPE
   661  GSRRKGITLT RILNKKLLSR HRNKNTMNGA PVEPCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 124 nTPM
spleen: 39 nTPM
adipose tissue: 37 nTPM
parathyroid gland: 27 nTPM
blood vessel: 26 nTPM
retina: 23 nTPM

Single-cell type

adrenal cortex cells: 1000 nCPM
adipocytes: 248 nCPM
cone photoreceptor cells: 219 nCPM
retinal bipolar cells: 184 nCPM
pericytes: 129 nCPM
rod photoreceptor cells: 108 nCPM

Immune cell

naive CD4 T-cell: 0.5 nTPM
NK-cell: 0.4 nTPM
myeloid DC: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

white matter: 33 nTPM
thalamus: 28 nTPM
medulla oblongata: 25 nTPM
midbrain: 23 nTPM
spinal cord: 23 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD2 as an antibody target. Whether an autoantibody or antibody against C2CD2 could matter depends on whether native C2CD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2CD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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