Seroatlas · Human Serome Atlas

SYT8

Synaptotagmin-8

Also known as: DKFZp434K0322, SYT8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBV8
Gene
SYT8
Ensembl
ENSG00000149043
Chromosome
11
Canonical length
387 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli fibrillar center,Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q8NBV8|SYT8
     1  MGHPPVSPSA PAPAGTTAIP GLIPDLVAGT PWPRWALIAG ALAAGVLLVS CLLCAACCCC
    61  RRHRKKPRDK ESVGLGSARG TTTTHLVQPD VDGLESSPGD AQQWGCLQLS LEFDFGSQEI
   121  RVGLRQAADL RPGGTVDPYA RVSVSTQAGH RHETKVHRGT LCPVFDETCC FHIPQAELPG
   181  ATLQVQLFNF KRFSGHEPLG ELRLPLGTVD LQHVLEHWYL LGPPAATQPE QVGELCFSLR
   241  YVPSSGRLTV VVLEARGLRP GLAEPYVKVQ LMLNQRKWKK RKTATKKGTA APYFNEAFTF
   301  LVPFSQVQNV DLVLAVWDRS LPLRTEPVGK VHLGARASGQ PLQHWADMLA HARRPIAQRH
   361  PLRPAREVDR MLALQPRLRL RLPLPHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • skin: 65 nTPM
  • urinary bladder: 36 nTPM
  • esophagus: 28 nTPM
  • salivary gland: 19 nTPM
  • pancreas: 14 nTPM
  • gallbladder: 13 nTPM

Single-cell type

  • breast myoepithelial cells: 202 nCPM
  • ocular epithelial cells: 131 nCPM
  • basal keratinocytes: 81 nCPM
  • papillary tip epithelial cells: 72 nCPM
  • urothelial cells: 71 nCPM
  • prostatic hillock cells: 56 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.2 nTPM
  • hippocampal formation: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
-0.24
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT8 as an antibody target. Whether an autoantibody or antibody against SYT8 could matter depends on whether native SYT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT8 is annotated at the cell surface, where native SYT8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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