Seroatlas · Human Serome Atlas

SYT13

Synaptotagmin-13

Also known as: KIAA1427, SYT13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L8C5
Gene
SYT13
Ensembl
ENSG00000019505
Chromosome
11
Canonical length
426 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q7L8C5|SYT13
     1  MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ
    61  QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS
   121  RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL
   181  EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT
   241  LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA
   301  ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI
   361  MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM
   421  WHQLHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 44 nTPM
  • hypothalamus: 27 nTPM
  • cerebellum: 27 nTPM
  • amygdala: 22 nTPM
  • gallbladder: 20 nTPM
  • hippocampal formation: 17 nTPM

Single-cell type

  • neuroendocrine cells: 258 nCPM
  • parietal cells: 81 nCPM
  • somatotrophs: 70 nCPM
  • pancreatic islet cells: 53 nCPM
  • other brain neurons: 49 nCPM
  • brain excitatory neurons: 42 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 120 nTPM
  • hypothalamus: 77 nTPM
  • hippocampal formation: 70 nTPM
  • basal ganglia: 65 nTPM
  • white matter: 64 nTPM
  • pons: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.69
gnomAD missense Z
0.36
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT13 as an antibody target. Whether an autoantibody or antibody against SYT13 could matter depends on whether native SYT13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT13 is annotated at the cell surface, where native SYT13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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