Seroatlas · Human Serome Atlas

PRKCA

Protein kinase C alpha type

Also known as: KPCA_HUMAN, PKCA, PKCalpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17252
Gene
PRKCA
Ensembl
ENSG00000154229
Chromosome
17
Canonical length
672 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>P17252|PRKCA
     1  MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF
    61  GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS
   121  LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA
   181  KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL
   241  SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME
   301  LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG
   361  TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV
   421  NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA
   481  DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG
   541  EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI
   601  DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN
   661  PQFVHPILQS AV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 33 nTPM
  • cerebral cortex: 29 nTPM
  • amygdala: 28 nTPM
  • retina: 28 nTPM
  • basal ganglia: 24 nTPM
  • midbrain: 20 nTPM

Single-cell type

  • bergmann glia: 1,774 nCPM
  • retinal bipolar cells: 1,304 nCPM
  • oligodendrocyte progenitor cells: 1,181 nCPM
  • astrocytes: 1,157 nCPM
  • adrenal cortex cells: 995 nCPM
  • choroid plexus epithelial cells: 988 nCPM

Immune cell

  • naive CD4 T-cell: 1.2 nTPM
  • non-classical monocyte: 1.1 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • MAIT T-cell: 0.5 nTPM
  • plasmacytoid DC: 0.4 nTPM

Brain region

  • hippocampal formation: 174 nTPM
  • cerebral cortex: 119 nTPM
  • thalamus: 93 nTPM
  • medulla oblongata: 91 nTPM
  • amygdala: 89 nTPM
  • midbrain: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.37
gnomAD missense Z
3.22
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCA as an antibody target. Whether an autoantibody or antibody against PRKCA could matter depends on whether native PRKCA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCA is annotated at the cell surface, where native PRKCA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKCA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKCA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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