Seroatlas · Human Serome Atlas

MCTP2

Multiple C2 and transmembrane domain-containing protein 2

Also known as: FLJ11175, FLJ33303, MCTP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DN12
Gene: MCTP2
Ensembl: ENSG00000140563
Chromosome: 15
Canonical length: 878 aa
Protein class: Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Located in cytosol; membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>Q6DN12|MCTP2
     1  MDLDKPSVWG SLKQRTRPLL INLSKKKVKK NPSKPPDLRA RHHLDRRLSL SVPDLLEAEA
    61  LAPEGRPYSG PQSSYTSVPS SLSTAGIFPK SSSSSLKQSE EELDWSQEEA SHLHVVETDS
   121  EEAYASPAER RRVSSNGIFD LQKTSLGGDA PEEPEKLCGS SDLNASMTSQ HFEEQSVPGE
   181  ASDGLSNLPS PFAYLLTIHL KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP
   241  VWDEIVVLPI QSLDQKLRVK VYDRDLTTSD FMGSAFVILS DLELNRTTEH ILKLEDPNSL
   301  EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSSLIR NLRLSESLKK NQLWNGIISI
   361  TLLEGKNVSG GSMTEMFVQL KLGDQRYKSK TLCKSANPQW QEQFDFHYFS DRMGILDIEV
   421  WGKDNKKHEE RLGTCKVDIS ALPLKQANCL ELPLDSCLGA LLMLVTLTPC AGVSVSDLCV
   481  CPLADLSERK QITQRYCLQN SLKDVKDVGI LQVKVLKAAD LLAADFSGKS DPFCLLELGN
   541  DRLQTHTVYK NLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKPPDFLGKV AIPLLSIRDG
   601  QPNCYVLKNK DLEQAFKGVI YLEMDLIYNP VKASIRTFTP REKRFVEDSR KLSKKILSRD
   661  VDRVKRITMA IWNTMQFLKS CFQWESTLRS TIAFAVFLIT VWNFELYMIP LALLLIFVYN
   721  FIRPVKGKVS SIQDSQESTD IDDEEDEDDK ESEKKGLIER IYMVQDIVST VQNVLEEIAS
   781  FGERIKNTFN WTVPFLSSLA CLILAAATII LYFIPLRYII LIWGINKFTK KLRNPYSIDN
   841  NELLDFLSRV PSDVQKVQYA ELKLCSSHSP LRKKRSAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCTP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

spleen: 20 nTPM
placenta: 18 nTPM
bone marrow: 15 nTPM
rectum: 11 nTPM
colon: 9.4 nTPM
epididymis: 8.2 nTPM

Single-cell type

neutrophils: 4,073 nCPM
neutrophil progenitors: 1,213 nCPM
nk-cells: 1,095 nCPM
hematopoietic stem cells: 794 nCPM
mesothelial cells: 622 nCPM
mast cells: 603 nCPM

Immune cell

neutrophil: 31 nTPM
eosinophil: 12 nTPM
NK-cell: 10 nTPM
basophil: 5.9 nTPM
gdT-cell: 5.7 nTPM
naive B-cell: 3.4 nTPM

Brain region

cerebral cortex: 18 nTPM
hypothalamus: 8.8 nTPM
basal ganglia: 6.7 nTPM
thalamus: 5.8 nTPM
hippocampal formation: 4.8 nTPM
choroid plexus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -1.42
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCTP2 as an antibody target. Whether an autoantibody or antibody against MCTP2 could matter depends on whether native MCTP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCTP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCTP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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