Seroatlas · Human Serome Atlas

ESYT2

Extended synaptotagmin-2

Also known as: CHR2SYT, ESYT2_HUMAN, FAM62B, KIAA1228

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0FGR8
Gene
ESYT2
Ensembl
ENSG00000117868
Chromosome
7
Canonical length
921 aa
Protein class
Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis; endoplasmic reticulum-plasma membrane tethering; and lipid transport. Located in several cellular components, including cytoplasmic side of plasma membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

921 residues, UniProt reviewed canonical sequence.

>A0FGR8|ESYT2
     1  MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR
    61  RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF
   121  ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA
   181  CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV
   241  DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
   301  RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV
   361  LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV
   421  GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE
   481  KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL
   541  YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
   601  EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR
   661  ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA
   721  QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT
   781  TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK
   841  THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
   901  AKGWTQWYDL TEDGTRPQAM T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESYT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 70 nTPM
  • adipose tissue: 48 nTPM
  • ovary: 45 nTPM
  • skeletal muscle: 42 nTPM
  • tongue: 39 nTPM
  • esophagus: 38 nTPM

Single-cell type

  • somatotrophs: 923 nCPM
  • vascular smooth muscle cells: 875 nCPM
  • thymocytes: 656 nCPM
  • innate lymphoid cells: 584 nCPM
  • endometrial ciliated cells: 577 nCPM
  • granulosa cells: 567 nCPM

Immune cell

  • gdT-cell: 5.9 nTPM
  • naive CD8 T-cell: 5.3 nTPM
  • NK-cell: 5.1 nTPM
  • memory CD4 T-cell: 4.7 nTPM
  • naive CD4 T-cell: 4.5 nTPM
  • memory CD8 T-cell: 4.3 nTPM

Brain region

  • thalamus: 49 nTPM
  • cerebral cortex: 48 nTPM
  • hippocampal formation: 46 nTPM
  • hypothalamus: 44 nTPM
  • pons: 42 nTPM
  • midbrain: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
0.55
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ESYT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ESYT2 as an antibody target. Whether an autoantibody or antibody against ESYT2 could matter depends on whether native ESYT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ESYT2 is annotated at the cell surface, where native ESYT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ESYT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ESYT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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