Seroatlas · Human Serome Atlas

SYTL2

Synaptotagmin-like protein 2

Also known as: CHR11SYT, exophilin-4, FLJ20163, FLJ21219, KIAA1597, MGC102768, PPP1R151, SGA72M, SLP2, SYTL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCH5
Gene: SYTL2
Ensembl: ENSG00000137501
Chromosome: 11
Canonical length: 934 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

934 residues, UniProt reviewed canonical sequence.

>Q9HCH5|SYTL2
     1  MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS GQWFYEAKAK
    61  RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV NNVNKDAFLP PELAGVVEEP
   121  EEDAAPASPS SSVVNPASSV IDMSQENTRK PNVSPEKRKN PFNSSKLPEG HSSQQTKNEQ
   181  SKNGRTGLFQ TSKEDELSES KEKSTVADTS IQKLEKSKQT LPGLSNGSQI KAPIPKARKM
   241  IYKSTDLNKD DNQSFPRQRT DSLKARGAPR GILKRNSSSS STDSETLRYN HNFEPKSKIV
   301  SPGLTIHERI SEKEHSLEDN SSPNSLEPLK HVRFSAVKDE LPQSPGLIHG REVGEFSVLE
   361  SDRLKNGMED AGDTEEFQSD PKPSQYRKPS LFHQSTSSPY VSKSETHQPM TSGSFPINGL
   421  HSHSEVLTAR PQSMENSPTI NEPKDKSSEL TRLESVLPRS PADELSHCVE PEPSQVPGGS
   481  SRDRQQGSEE EPSPVLKTLE RSAARKMPSK SLEDISSDSS NQAKVDNQPE ELVRSAEDVS
   541  TVPTQPDNPF SHPDKLKRMS KSVPAFLQDE SDDRETDTAS ESSYQLSRHK KSPSSLTNLS
   601  SSSGMTSLSS VSGSVMSVYS GDFGNLEVKG NIQFAIEYVE SLKELHVFVA QCKDLAAADV
   661  KKQRSDPYVK AYLLPDKGKM GKKKTLVVKK TLNPVYNEIL RYKIEKQILK TQKLNLSIWH
   721  RDTFKRNSFL GEVELDLETW DWDNKQNKQL RWYPLKRKTA PVALEAENRG EMKLALQYVP
   781  EPVPGKKLPT TGEVHIWVKE CLDLPLLRGS HLNSFVKCTI LPDTSRKSRQ KTRAVGKTTN
   841  PIFNHTMVYD GFRPEDLMEA CVELTVWDHY KLTNQFLGGL RIGFGTGKSY GTEVDWMDST
   901  SEEVALWEKM VNSPNTWIEA TLPLRMLLIA KISK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYTL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

stomach: 119 nTPM
rectum: 69 nTPM
colon: 48 nTPM
urinary bladder: 46 nTPM
blood vessel: 45 nTPM
cerebral cortex: 33 nTPM

Single-cell type

foveolar cells: 1,989 nCPM
goblet cells: 942 nCPM
urothelial cells: 557 nCPM
papillary tip epithelial cells: 428 nCPM
salivary duct cells: 368 nCPM
prostatic hillock cells: 354 nCPM

Immune cell

MAIT T-cell: 24 nTPM
gdT-cell: 14 nTPM
memory CD8 T-cell: 8.5 nTPM
NK-cell: 4.3 nTPM
naive CD8 T-cell: 4.1 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebral cortex: 75 nTPM
white matter: 63 nTPM
medulla oblongata: 61 nTPM
hypothalamus: 56 nTPM
basal ganglia: 45 nTPM
spinal cord: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: -1.2
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYTL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYTL2 as an antibody target. Whether an autoantibody or antibody against SYTL2 could matter depends on whether native SYTL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYTL2 is annotated at the cell surface, where native SYTL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYTL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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