Seroatlas · Human Serome Atlas

SYT17

Synaptotagmin-17

Also known as: Syt-17, SYT17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSW7
Gene
SYT17
Ensembl
ENSG00000103528
Chromosome
16
Canonical length
474 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in positive regulation of dendrite extension and regulation of postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q9BSW7|SYT17
     1  MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL GPFPAQTPPW
    61  LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK STYSLTRRIS SLESRRPSSP
   121  LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL
   181  SKYQLGMLHF STQYDLLHNH LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK
   241  NSKQTGVKRK TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV
   301  DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ TDVSQGSDPF
   361  VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE LENASLVFTV FGHNMKSSND
   421  FIGRIVIGQY SSGPSETNHW RRMLNTHRTA VEQWHSLRSR AECDRVSPAS LEVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 28 nTPM
  • parathyroid gland: 24 nTPM
  • amygdala: 22 nTPM
  • hypothalamus: 22 nTPM
  • hippocampal formation: 22 nTPM
  • midbrain: 18 nTPM

Single-cell type

  • ependymal cells: 224 nCPM
  • renal collecting duct intercalated cells: 218 nCPM
  • astrocytes: 180 nCPM
  • pituitary stem cells: 167 nCPM
  • oligodendrocyte progenitor cells: 158 nCPM
  • respiratory ionocytes: 137 nCPM

Immune cell

  • non-classical monocyte: 20 nTPM
  • naive B-cell: 19 nTPM
  • memory B-cell: 7.8 nTPM
  • intermediate monocyte: 6.2 nTPM
  • myeloid DC: 2.2 nTPM
  • total PBMC: 0.9 nTPM

Brain region

  • midbrain: 52 nTPM
  • thalamus: 49 nTPM
  • hippocampal formation: 44 nTPM
  • basal ganglia: 43 nTPM
  • hypothalamus: 39 nTPM
  • cerebral cortex: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
1.18
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT17 as an antibody target. Whether an autoantibody or antibody against SYT17 could matter depends on whether native SYT17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT17 is annotated at the cell surface, where native SYT17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...