C2CD4D
C2 calcium-dependent domain-containing protein 4D
Also known as: C2D4D_HUMAN, FAM148D
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B7Z1M9
- Gene
- C2CD4D
- Ensembl
- ENSG00000225556
- Chromosome
- 1
- Canonical length
- 353 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C2CD4D in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
353 residues, UniProt reviewed canonical sequence.
>B7Z1M9|C2CD4D
1 MWLLEKAGYK VGAAEPAARW APSGLFSKRR APGPPTSACP NVLTPDRIPQ FFIPPRLPDP
61 GGAVPAARRH VAGRGLPATC SLPHLAGREG WAFLPESPHT RRRESLFHGP PPAPAGGLPA
121 AQSRLHVSAP DLRLCRAPDS DTASSPDSSP FGSPRPGLGR RRVSRPHSLS PEKASSADTS
181 PHSPRRAGPP TPPLFHLDFL CCQLRPTRES VLRLGPRGGQ LRLSTEYQAG PGRLRLRLVS
241 AEGLPRPRSR PGSGGGGCCV VLRLRPRVRP REQQSRVVKC SANPIFNEDF FFDGLGPPDL
301 AARSLRAKVL DRGAGLRRDV LLGECETPLI ALLPPLGGGL GPGSSLAPTH LSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C2CD4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 2.2 nTPM
Expression across tissuesHPA
Tissue
- skin: 2.2 nTPM
- salivary gland: 1.7 nTPM
- spinal cord: 1.7 nTPM
- cerebellum: 0.9 nTPM
- pancreas: 0.9 nTPM
- cerebral cortex: 0.8 nTPM
Single-cell type
- tuft cells: 23 nCPM
- syncytiotrophoblasts: 13 nCPM
- innate lymphoid cells: 8.8 nCPM
- breast lactating cells: 7.9 nCPM
- fallopian tube ciliated cells: 7.2 nCPM
- medullary thymic epithelial cells: 7.2 nCPM
Immune cell
- T-reg: 0.6 nTPM
- MAIT T-cell: 0.5 nTPM
- memory CD4 T-cell: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- white matter: 10 nTPM
- cerebral cortex: 8.9 nTPM
- pons: 7.5 nTPM
- amygdala: 7.2 nTPM
- medulla oblongata: 7.2 nTPM
- midbrain: 6.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0.13
- gnomAD missense Z
- 0.56
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C2CD4D as an antibody target. Whether an autoantibody or antibody against C2CD4D could matter depends on whether native C2CD4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C2CD4D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C2CD4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...