Seroatlas · Human Serome Atlas

SYT15

Synaptotagmin-15

Also known as: CHR10SYT, SYT15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQS2
Gene: SYT15
Ensembl: ENSG00000204176
Chromosome: 10
Canonical length: 421 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9BQS2|SYT15
     1  MAEQLALVIG GTIGGLLLLL LIGASCCLWR RFCATLTYEE LPGTPAMATT AASSGQRDRP
    61  CQPHARTQLS RPPAVPFVVP PTLQGRDWVP LHSGEWADAP WDPCPASELL PHTSSGGLGD
   121  ACMVGAINPE LYKFPEDKSE TDFPDGCLGR LWFSVEYEQE AERLLVGLIK AQHLQAPSET
   181  CSPLVKLYLL PDERRFLQSK TKRKTSNPQF DEHFIFQVSS KTITQRVLKF SVYHVDRQRK
   241  HQLLGQVLFP LKNETLVGDC RRVIWRDLEA ESLEPPSEFG DLQFCLSYND YLSRLTVVVL
   301  RAKGLRLQED RGIVSVFVKV SLMNHNKFVK CKKTSAVLGS INPVYNETFS FKADATELDT
   361  ASLSLTVVQN MEGDKSQQLG RVVVGPYMYT RGRELEHWDE MLSKPKELVK RWHALCRTTE
   421  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

lung: 7.7 nTPM
skin: 5.3 nTPM
cerebral cortex: 4.5 nTPM
pancreas: 3.5 nTPM
lymph node: 3.4 nTPM
placenta: 3.4 nTPM

Single-cell type

alveolar cells type 1: 9.8 nCPM
vascular endothelial cells: 9.1 nCPM
alveolar cells type 2: 3.4 nCPM
lymphatic endothelial cells: 2.9 nCPM
kupffer cells: 2 nCPM
transitional alveolar cells: 2 nCPM

Immune cell

intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1 nTPM
classical monocyte: 0.5 nTPM
gdT-cell: 0.5 nTPM
MAIT T-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

cerebral cortex: 32 nTPM
hippocampal formation: 29 nTPM
amygdala: 21 nTPM
pons: 20 nTPM
basal ganglia: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.06

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT15 as an antibody target. Whether an autoantibody or antibody against SYT15 could matter depends on whether native SYT15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT15 is annotated at the cell surface, where native SYT15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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