Seroatlas · Human Serome Atlas

RASA2

Ras GTPase-activating protein 2

Also known as: GAP1M, RASA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15283
Gene: RASA2
Ensembl: ENSG00000155903
Chromosome: 3
Canonical length: 850 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

850 residues, UniProt reviewed canonical sequence.

>Q15283|RASA2
     1  MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL LPYLGPHKMR
    61  DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ YLSFYVYDKN VLQRDLRIGK
   121  VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ GKVHLELKLN ELITENGTVC QQLVVHIKAC
   181  HGLPLINGQS CDPYATVSLV GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ
   241  FQVEEEDIEK LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS
   301  SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL SEICRDKNDA
   361  VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS LATRCLDEMM KIVGGHYLKV
   421  TLKPILDEIC DSSKSCEIDP IKLKEGDNVE NNKENLRYYV DKLFNTIVKS SMSCPTVMCD
   481  IFYSLRQMAT QRFPNDPHVQ YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL
   541  ISKTIQTLGS WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT
   601  SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI YTIPVKNILA
   661  VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV LCRVSRCNQN RLSFYHPSVY
   721  LNGNWLCCQE TGENTLGCKP CTAGVPADIQ IDIDEDRETE RIYSLFTLSL LKLQKMEEAC
   781  GTIAVYQGPQ KEPDDYSNFV IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS
   841  KENPIVGKAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
lymph node: 20 nTPM
tonsil: 16 nTPM
appendix: 14 nTPM
retina: 13 nTPM
thymus: 12 nTPM

Single-cell type

neutrophils: 1,229 nCPM
nk-cells: 696 nCPM
neutrophil progenitors: 681 nCPM
urothelial cells: 644 nCPM
innate lymphoid cells: 642 nCPM
t-cells: 529 nCPM

Immune cell

naive CD4 T-cell: 14 nTPM
naive CD8 T-cell: 12 nTPM
neutrophil: 11 nTPM
NK-cell: 10 nTPM
memory CD8 T-cell: 9.7 nTPM
MAIT T-cell: 9.4 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 14 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RASA2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 933 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Noonan syndrome 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 1.88
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASA2 as an antibody target. Whether an autoantibody or antibody against RASA2 could matter depends on whether native RASA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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