PIK3C2G

Protein identityUniProt · HPA

UniProt accession

O75747

Gene

PIK3C2G

Ensembl

ENSG00000139144

Chromosome

12

Canonical length

1486 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Centrosome

OverviewNCBI Gene

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

1486 residues, UniProt reviewed canonical sequence.

>O75747|PIK3C2G
     1  MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK IPHYESEIDE
    61  NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ VSKAPAIGFS PSVLPKPQNT
   121  NKECSWGSPI GKHHGADDSR FSILAPSFTS LDKINLEKEL ENENHNYHIG FESSIPPTNS
   181  SFSSDFMPKE ENKRSGHVNI VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS
   241  SNTSLASFCN KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP
   301  LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG SHKMFQKDKS
   361  VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK VSRQCLLTLI RKYDFHLKYL
   421  LKTQENVYNI IEEVKKICSV LGCVETKQIT DAVNELSLIL QRKGENFYQS SETSAKGLIE
   481  KVTTELSTSI YQLINVYCNS FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV
   541  HSYKAFSFTC WLTYAGKKLC QVRNYRNIPD KKLFFFLVNW NETINFPLEI KSLPRESMLT
   601  VKLFGIACAT NNANLLAWTC LPLFPKEKSI LGSMLFSMTL QSEPPVEMIT PGVWDVSQPS
   661  PVTLQIDFPA TGWEYMKPDS EENRSNLEEP LKECIKHIAR LSQKQTPLLL SEEKKRYLWF
   721  YRFYCNNENC SLPLVLGSAP GWDERTVSEM HTILRRWTFS QPLEALGLLT SSFPDQEIRK
   781  VAVQQLDNLL NDELLEYLPQ LVQAVKFEWN LESPLVQLLL HRSLQSIQVA HRLYWLLKNA
   841  ENEAYFKSWY QKLLAALQFC AGKALNDEFS KEQKLIKILG DIGERVKSAS DHQRQEVLKK
   901  EIGRLEEFFQ DVNTCHLPLN PALCIKGIDH DACSYFTSNA LPLKITFINA NPMGKNISII
   961  FKAGDDLRQD MLVLQLIQVM DNIWLQEGLD MQMIIYRCLS TGKDQGLVQM VPDAVTLAKI
  1021  HRHSGLIGPL KENTIKKWFS QHNHLKADYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI
  1081  MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNP QHFQDFVELC
  1141  CRAYNIIRKH SQLLLNLLEM MLYAGLPELS GIQDLKYVYN NLRPQDTDLE ATSHFTKKIK
  1201  ESLECFPVKL NNLIHTLAQM SAISPAKSTS QTFPQESCLL STTRSIERAT ILGFSKKSSN
  1261  LYLIQVTHSN NETSLTEKSF EQFSKLHSQL QKQFASLTLP EFPHWWHLPF TNSDHRRFRD
  1321  LNHYMEQILN VSHEVTNSDC VLSFFLSEAV QQTVEESSPV YLGEKFPDKK PKVQLVISYE
  1381  DVKLTILVKH MKNIHLPDGS APSAHVEFYL LPYPSEVRRR KTKSVPKCTD PTYNEIVVYD
  1441  EVTELQGHVL MLIVKSKTVF VGAINIRLCS VPLDKEKWYP LGNSII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3C2G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

20 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIK3C2G.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 200 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Esophageal atresia/tracheoesophageal fistula

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0

gnomAD missense Z

-0.97

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell migration
• chemotaxis
• host-mediated perturbation of viral process
• phosphatidylinositol 3-kinase/protein kinase B signal transduction
• phosphatidylinositol-3-phosphate biosynthetic process
• phosphatidylinositol-mediated signaling

Molecular functions

• 1-phosphatidylinositol-3-kinase activity
• 1-phosphatidylinositol-4-phosphate 3-kinase activity
• ATP binding
• phosphatidylinositol binding
• phosphatidylinositol kinase activity

Cellular components

• cytoplasm
• cytosol
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
• Phosphatidylinositol 3-/4-kinase, catalytic domain
• Phosphoinositide 3-kinase, accessory (PIK) domain
• Phox homology
• C2 phosphatidylinositol 3-kinase-type domain
• Protein kinase-like domain superfamily
• Phosphatidylinositol 3-/4-kinase
• Armadillo-type fold
• Phosphatidylinositol 3-/4-kinase, conserved site
• Ubiquitin-like domain superfamily
• C2 domain superfamily
• PX domain superfamily
• Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
• Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
• C2 domain
• Phosphatidylinositol 3- and 4-kinase
• Phosphoinositide 3-kinase family, accessory domain (PIK domain)
• PX domain
• Phosphoinositide 3-kinase C2
• PI3-kinase family, ras-binding domain
• Phosphatidylinositol 3-kinase C2-gamma, catalytic domain

KeywordsUniProt

• ATP-binding
• Chemotaxis
• Kinase
• Lipid metabolism
• Membrane
• Nucleotide-binding
• Transferase